The Role of 68Ga FAPI-04 and 18F-FDG PET/CT in Detecting Liver Metastases in Different Types of Cancer.

IF 1 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Nuklearmedizin-nuclear Medicine Pub Date : 2023-08-01 DOI:10.1055/a-2127-7699

İhsan Kaplan, Ferat Kepenek, Yunus Güzel, Canan Can, Halil Kömek

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引用次数: 1

Abstract

Objective: We compared the diagnostic accuracies of ⁶⁸Ga FAPI-04 PET/CT and ¹⁸F-FDG PET/CT for detecting liver metastases (LMs) in patients with different cancer types.

Materials and methods: This retrospective study included 63 patients with liver lesions who underwent ¹⁸F-FDG PET/CT and ⁶⁸Ga-FAPI-04 PET/CT between May 2020 and May 2022. Patients with histopathologically confirmed primary diagnoses, data that could be accessed retrospectively, liver lesions confirmed by biopsy over at least 3-6 months of follow-up (via ultrasonography, CT, magnetic resonance imaging, PET/CT, or laboratory tests) were included. Patients with secondary malignancies or primary liver malignancies, and/or who could not be followed-up, were excluded.

Results: Of the 63 total patients, 34 (54%) were female, and the mean age was 61 (30-92) years. There were 582 LMs in 51 patients and 35 benign liver lesions in 20 (12 patients had only benign and 8 both benign and malignant lesions). Of the 582 LMs, 472 (81.1%) evidenced ¹⁸F-FDG uptake and 572 (98.2%) ⁶⁸Ga-FAPI uptake. The diagnostic accuracies of ⁶⁸Ga-FAPI PET/CT and ¹⁸F-FDG PET/CT were 98% and 82%, respectively (p < 0.001; McNemar test). When the LMs were compared, the maximum standardized uptake (SUVmax) value was significantly higher on ¹⁸F-FDG PET/CT than ⁶⁸Ga-FAPI PET/CT (median: 6.0 vs. 5.4; p = 0.016). However, the LM-to-background ratio (TBR) was significantly higher on ⁶⁸Ga-FAPI PET/CT than ¹⁸F-FDG PET/CT (median: 4.1 vs. 2.1; p < 0.001).

Conclusion: ⁶⁸Ga-FAPI PET/CT detected more LMs than did ¹⁸F-FDG PET/CT, and TBR was significantly higher on ⁶⁸Ga-FAPI PET/CT than ¹⁸F-FDG PET/CT.

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68Ga FAPI-04和18F-FDG PET/CT在不同类型肿瘤肝转移中的作用

目的:比较68Ga FAPI-04 PET/CT与18F-FDG PET/CT对不同肿瘤类型患者肝转移的诊断准确性。材料和方法:本回顾性研究纳入了63例肝脏病变患者，于2020年5月至2022年5月期间接受了18F-FDG PET/CT和68Ga-FAPI-04 PET/CT检查。纳入了经组织病理学证实的初步诊断、可回顾性获取的资料、至少3-6个月随访期间(超声、CT、磁共振、PET/CT或实验室检查)活检证实的肝脏病变的患者。排除继发性恶性肿瘤或原发性肝脏恶性肿瘤患者和/或无法随访的患者。结果:63例患者中，女性34例(54%)，平均年龄61(30 ~ 92)岁。51例LMs 582例，20例肝良性病变35例(仅良12例，良恶性8例)。在582例LMs中，472例(81.1%)证实摄取18F-FDG, 572例(98.2%)证实摄取68Ga-FAPI。68Ga-FAPI PET/CT和18F-FDG PET/CT的诊断准确率分别为98%和82% (p < 0.001;McNemar检验法测试)。当比较LMs时，18F-FDG PET/CT的最大标准化摄取(SUVmax)值显著高于68Ga-FAPI PET/CT(中位数:6.0 vs. 5.4;P = 0.016)。然而，68Ga-FAPI PET/CT的LM-to-background ratio (TBR)明显高于18F-FDG PET/CT(中位数:4.1 vs. 2.1;P < 0.001)。结论:68Ga-FAPI PET/CT比18F-FDG PET/CT检出更多LMs, TBR明显高于18F-FDG PET/CT。

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来源期刊

Nuklearmedizin-nuclear Medicine 医学-核医学

CiteScore

1.70

自引率

13.30%

发文量

267

审稿时长

>12 weeks

期刊介绍： Als Standes- und Fachorgan (Organ von Deutscher Gesellschaft für Nuklearmedizin (DGN), Österreichischer Gesellschaft für Nuklearmedizin und Molekulare Bildgebung (ÖGN), Schweizerischer Gesellschaft für Nuklearmedizin (SGNM, SSNM)) von hohem wissenschaftlichen Anspruch befasst sich die CME-zertifizierte Nuklearmedizin/ NuclearMedicine mit Diagnostik und Therapie in der Nuklearmedizin und dem Strahlenschutz: Originalien, Übersichtsarbeiten, Referate und Kongressberichte stellen aktuelle Themen der Diagnose und Therapie dar. Ausführliche Berichte aus den DGN-Arbeitskreisen, Nachrichten aus Forschung und Industrie sowie Beschreibungen innovativer technischer Geräte, Einrichtungen und Systeme runden das Konzept ab. Die Abstracts der Jahrestagungen dreier europäischer Fachgesellschaften sind Bestandteil der Kongressausgaben. Nuklearmedizin erscheint regelmäßig mit sechs Ausgaben pro Jahr und richtet sich vor allem an Nuklearmediziner, Radiologen, Strahlentherapeuten, Medizinphysiker und Radiopharmazeuten.