Age-related changes in the pharmacokinetics of meloxicam after intravenous administration in sheep

IF 1.5 4区农林科学 Q3 PHARMACOLOGY & PHARMACY

Journal of veterinary pharmacology and therapeutics Pub Date : 2023-07-24 DOI:10.1111/jvp.13404

Devran Coskun, Orhan Corum, Duygu Durna Corum, Gul Cetin, Mehmet Irmak, Hatice Rumeysa Ceyhan, Kamil Uney

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引用次数: 1

Abstract

The pharmacokinetics of meloxicam was studied in 1-, 6-, and 12-month-old sheep following a single intravenous (i.v.) dose of 1 mg/kg. The experiments were carried out when the Romanov sheep were 1 month old (7.93 ± 0.91 kg), 6 months old (27.47 ± 4.91 kg), and 12 months old (37.10 ± 3.64 kg). Meloxicam concentration in plasma was determined by high-performance liquid chromatography and the data collected were evaluated by non-compartmental kinetic analysis. Meloxicam was detected in the plasma up to 72 h following i.v. administration in all age groups. The volume of distribution at steady state (V_dss) and total body clearance (Cl_T) were significantly higher in 1-month-old (304.87 mL/kg and 16.57 mL/h/kg) than in 12-month-old (193.43 mL/kg and 10.50 mL/h/kg) sheep. The area under the concentration–time curve from 0 to 72 h value of meloxicam was lower in 1-month-old (58.51 h*μg/mL) compared to 12-month-old (92.59 h*μg/mL) sheep. There was no difference in t_1/2ʎz value in different age groups. The body extraction ratio values for meloxicam ranged from 0.0186 to 0.0719 after i.v. administration in all age groups. Meloxicam showed an increase in plasma concentration and a decrease in V_dss and Cl_T in 12-month-old compared to 1-month-old sheep. Compared to 1-month-old and 12-month-old sheep, there was no difference in these parameters in 6-month-old sheep. Because the age of sheep has an influence on the pharmacokinetics of meloxicam, dosage apparently may need to be adjusted for age.

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绵羊静脉给药后美洛昔康药代动力学的年龄相关性变化

研究了美洛昔康在1、6和12个月大的绵羊体内的药代动力学 mg/kg。实验是在罗曼诺夫羊1岁时进行的月龄（7.93 ± 0.91 kg），6 月龄（27.47 ± 4.91 kg）和12 月龄（37.10 ± 3.64 kg）。用高效液相色谱法测定血浆中美洛昔康的浓度，并用非房室动力学分析法评价所收集的数据。在血浆中检测到美洛昔康达72 h所有年龄组静脉注射后。1个月大婴儿的稳态分布体积（Vdss）和全身清除率（ClT）显著较高（304.87 mL/kg和16.57 mL/h/kg）比12个月大（193.43 mL/kg和10.50 mL/h/kg）绵羊。从0到72的浓度-时间曲线下的面积美洛昔康的h值在1个月大时较低（58.51 h*μg/mL）与12个月大（92.59 μg/mL）绵羊。不同年龄组的t1/2ʎz值没有差异。所有年龄组静脉给药后美洛昔康的身体提取比值在0.0186至0.0719之间。与1个月大的绵羊相比，美洛昔康显示12个月大绵羊的血浆浓度增加，Vdss和ClT降低。与1个月大和12个月大的绵羊相比，6个月大绵羊的这些参数没有差异。由于绵羊的年龄对美洛昔康的药代动力学有影响，因此可能需要根据年龄调整剂量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of veterinary pharmacology and therapeutics 农林科学-兽医学

CiteScore

3.10

自引率

15.40%

发文量

审稿时长

8-16 weeks

期刊介绍： The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.