Intergenerational Transmission of BMI and Educational Outcomes in Children and Adolescents.

IF 1 4区 医学 Q4 GENETICS & HEREDITY
Hekmat Alrouh, Elsje van Bergen, Conor Dolan, Dorret I Boomsma
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引用次数: 0

Abstract

Individual differences in educational attainment (EA) and physical health, as indexed by body mass index (BMI), are correlated within individuals and across generations. The aim of our study was to assess the transmission of these traits from parents to their offspring in childhood and adolescence. We analyzed BMI and EA in 13,916 families from the Netherlands. Data were available for 27,577 parents (mean age 33) and 26,855 of their offspring at 4 and 12 years of age. We employed structural equation modeling to simultaneously estimate the phenotypic transmission of BMI and EA from parents to offspring, the spousal correlations, and the residual child BMI-EA associations after accounting for intergenerational transmission and testing for gender differences therein. We found a significant intergenerational transmission of BMI to BMI in childhood (age 4; standardized regression coefficient β = .10) and adolescence (age 12; β = .20), and of EA to academic achievement in adolescence (β = .19). Cross-trait parent-to-offspring transmission was weak. All transmission effects were independent of parent or offspring gender. We observed within-person EA-BMI correlations that were negative in parents (∼-.09), positive in children (∼.05) and negative in adolescents (∼-.06). Residual EA-BMI were positive in children (∼.05) and insignificant in adolescents. Spousal correlations were .46 for EA, .21 for BMI, and ∼-.09 cross-trait. After accounting for spousal correlations, the intergenerational transmission for BMI and EA is mainly predictive within, but not across, traits. The within-person correlation between BMI and EA can change in direction between childhood and adulthood.

儿童和青少年BMI代际传递与教育成果。
以身体质量指数(BMI)为指标的受教育程度(EA)和身体健康的个体差异,在个体内部和代际之间都是相关的。我们研究的目的是评估这些特征在童年和青春期从父母传递给他们的后代。我们分析了来自荷兰的13916个家庭的BMI和EA。数据来自27,577位父母(平均年龄33岁)和26,855位他们4岁和12岁的子女。在考虑了代际传递和性别差异后,我们采用结构方程模型同时估计了BMI和EA从父母到后代的表型传递、配偶相关性以及剩余的儿童BMI-EA关联。我们发现BMI在儿童期(4岁;标准化回归系数β = .10)和青春期(12岁;β = 0.20), EA对青少年学业成绩的影响(β = 0.19)。跨性状亲代传代较弱。所有的传播效应与亲代或子代性别无关。我们观察到,人体内EA-BMI相关性在父母中为负(~ - 0.09),在儿童中为正(~ 0.05),在青少年中为负(~ - 0.06)。残余EA-BMI在儿童中呈阳性(~ 0.05),在青少年中不显著。EA的配偶相关性为0.46,BMI的配偶相关性为0.21,配偶相关性为~ -。09年cross-trait。在考虑配偶相关性后,BMI和EA的代际传递主要是在性状内预测,而不是在性状间预测。BMI和EA在人体内的相关性在儿童期和成年期可以改变方向。
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来源期刊
Twin Research and Human Genetics
Twin Research and Human Genetics 医学-妇产科学
CiteScore
1.50
自引率
11.10%
发文量
37
审稿时长
6-12 weeks
期刊介绍: Twin Research and Human Genetics is the official journal of the International Society for Twin Studies. Twin Research and Human Genetics covers all areas of human genetics with an emphasis on twin studies, genetic epidemiology, psychiatric and behavioral genetics, and research on multiple births in the fields of epidemiology, genetics, endocrinology, fetal pathology, obstetrics and pediatrics. Through Twin Research and Human Genetics the society aims to publish the latest research developments in twin studies throughout the world.
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