Madeline R Pike, Melissa L Engel, Emily Lipner, Constance Hammen, Patricia A Brennan
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引用次数: 0
Abstract
Prenatal maternal stress (PNMS) is linked to physical sequelae in offspring, including childhood asthma. This study sought to examine the roles of objective and subjective PNMS in the development of asthma at offspring ages 5 and 15. The sample included 815 mother-child dyads from the Mater Misericordiae Mothers' Hospital-University of Queensland Study of Pregnancy. PNMS was measured via retrospective self-report during pregnancy and 3-5 days after birth. Postnatal maternal stress was measured at offspring age 5. Objective PNMS was associated with elevated asthma risk at age 5 (OR 1.21, 95% CI 1.00, 1.45, p = 0.05), albeit not above concurrent postnatal stress. Sex moderated the association between PNMS and asthma at age 15, controlling for postnatal stress. Sex stratified analyses revealed a positive association between objective PNMS and age 15 asthma in females, but not males. Results provide evidence that PNMS may impact asthma outcomes in adolescence.
产前母亲压力（PNMS）与后代的身体后遗症有关，包括儿童哮喘。本研究旨在探讨客观和主观PNMS在5岁和15岁后代哮喘发展中的作用。样本包括815对来自圣母医院和昆士兰大学妊娠研究的母子二人组。在怀孕期间和出生后3-5天通过回顾性自我报告测量PNMS。在子代5岁时测量产后母亲压力。目的PNMS与5岁时哮喘风险升高相关（OR 1.21, 95% CI 1.00, 1.45, p = 0.05），但与并发的产后应激无关。性别调节了15岁时PNMS与哮喘之间的关系，控制了产后压力。性别分层分析显示，客观PNMS与15岁女性哮喘呈正相关，但与男性无关。结果提供了PNMS可能影响青少年哮喘结局的证据。
期刊介绍：
Child Psychiatry & Human Development is an interdisciplinary international journal serving the groups represented by child and adolescent psychiatry, clinical child/pediatric/family psychology, pediatrics, social science, and human development. The journal publishes research on diagnosis, assessment, treatment, epidemiology, development, advocacy, training, cultural factors, ethics, policy, and professional issues as related to clinical disorders in children, adolescents, and families. The journal publishes peer-reviewed original empirical research in addition to substantive and theoretical reviews.
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