Genetic alterations in prostate cancer as diagnostic and prognostic markers.

IF 0.6 4区医学 Q4 PATHOLOGY

Malaysian Journal of Pathology Pub Date : 2023-08-01

H Saeidi, P Ismail, C Samudi Raju, M G Khairul-Asri, I H Bakrin

引用次数: 0

Abstract

Prostate cancer is the second-most frequently diagnosed cancer in men worldwide. Serum prostatespecific antigen is currently used for the early detection of prostate cancer. However, new biomarkers are needed to decrease over diagnosis and over treatment of prostate cancer due to limitations of prostate-specific antigen. Recently, molecular biomarkers have shown promising results for diagnosis and prognosis of prostate cancer. Molecular biomarkers have improved the sensitivity and specificity of prostate-specific antigen and studies are ongoing to identify molecular biomarkers as a replacement for prostate-specific antigen. This review aims to give an overview of emerging molecular biomarkers for diagnosis and prognosis of prostate cancer.

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前列腺癌的遗传改变作为诊断和预后标志物。

前列腺癌是全球男性中第二大常被诊断的癌症。血清前列腺特异性抗原目前被用于前列腺癌的早期检测。然而，由于前列腺特异性抗原的局限性，需要新的生物标志物来减少前列腺癌的过度诊断和过度治疗。近年来，分子生物标志物在前列腺癌的诊断和预后方面显示出良好的效果。分子生物标志物提高了前列腺特异性抗原的敏感性和特异性，目前正在研究分子生物标志物作为前列腺特异性抗原的替代品。本文综述了近年来用于前列腺癌诊断和预后的分子生物标志物的研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Malaysian Journal of Pathology PATHOLOGY-

CiteScore

3.60

自引率

5.60%

发文量

期刊介绍： The Malaysian Journal of Pathology is the official journal of the College of Pathologists, Academy of Medicine Malaysia. The primary purpose of The Journal is to publish the results of study and research in Pathology, especially those that have particular relevance to human disease occurring in Malaysia and other countries in this region. The term PATHOLOGY will be interpreted in its broadest sense to include Chemical Pathology, Cytology, Experimental Pathology, Forensic Pathology, Haematology, Histopathology, Immunology, Medical Microbiology and Parasitology. The Journal aims to bring under one cover publications of regional interest embracing the various sub-specialities of Pathology. It is expected that the articles published would be of value not only to pathologists, but also to medical practitioners in search of a scientific basis for the problems encountered in their practice, and to those with an interest in diseases which occur in the tropics.