Detection and sensing of oral xenobiotics in edentulous patients rehabilitated with titanium dental implants: Insights from a scoping review

IF 4.3 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Prosthetic Dentistry Pub Date : 2024-11-01 DOI:10.1016/j.prosdent.2023.05.012

Pier Paolo Poli DDS, MSc, PhD , Mattia Manfredini DDS, MSc , Nadim Oliva DDS , Sofia Bettini DDS , Giovanni Damiani MD , Riccardo Goldoni BSc, MSc , Lucanos Strambini MSc, PhD , Sara Casati BSc, PhD , Massimo Del Fabbro BSc, MSc, PhD , Gianluca M. Tartaglia DDS, PhD

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引用次数: 0

Abstract

Statement of problem

Titanium has been considered the standard element in implant manufacturing. Recent studies have evaluated the role of titanium as a biological modulator of oral health. However, evidence regarding the association between the release of metal particles and peri-implantitis is lacking.

Purpose

The purpose of this scoping review was to evaluate the literature regarding the release of metal particles in peri-implant tissues correlated with the methods of detection and the local and systemic implications.

Material and methods

The study was performed in adherence with the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines and was registered with the National Institute for Health Research PROSPERO (Submission No. 275576; ID: CRD42021275576). A systematic search was conducted in the Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE via PubMed, Scopus, and Web of Science bibliographic databases, complemented by a manual evaluation. Only in vivo human studies written in the English language and published between January 2000 and June 2022 were included.

Results

In total, 10 studies were included according to eligibility criteria. Different tissues and analytic techniques were reported: the characterization technique most used was inductively coupled plasma mass spectrometry. All 10 studies analyzed the release of metal particles in patients with dental implants, continuously detecting titanium. None of the studies reported a significant association between metal particles and biological effects.

Conclusions

Titanium is still considered the material of choice in implant dentistry, despite the detection of metal particles in peri-implant tissues. Further studies are necessary to evaluate the association between analytes and local health or inflammatory status.

查看原文本刊更多论文

使用钛种植体进行修复的无牙患者口腔异种生物的检测和感应：范围综述的启示。

问题陈述：钛一直被认为是制造种植体的标准元素。最近的研究评估了钛作为口腔健康生物调节剂的作用。目的：本范围综述旨在评估与种植体周围组织中金属微粒释放相关的文献，包括检测方法以及对局部和全身的影响：本研究遵照《系统综述和荟萃分析扩展报告首选项》（Preferred Reporting Items for Systematic Review and Meta-Analyses extension for Scoping Reviews，PRISMA-ScR）指南进行，并在美国国家健康研究所（National Institute for Health Research PROSPERO）注册（提交编号：275576；ID：CRD42021275576）。在 Cochrane Central Register of Controlled Trials、EMBASE、MEDLINE via PubMed、Scopus 和 Web of Science 文献数据库中进行了系统检索，并辅以人工评估。仅纳入了 2000 年 1 月至 2022 年 6 月间发表的以英语撰写的活体人体研究：根据资格标准，共纳入了 10 项研究。报告采用了不同的组织和分析技术：最常用的表征技术是电感耦合等离子体质谱法。所有 10 项研究都分析了牙科植入物患者体内金属微粒的释放情况，并持续检测钛。这些研究均未报告金属微粒与生物效应之间存在明显关联：结论：尽管在种植体周围组织中检测到了金属微粒，但钛仍被认为是种植牙的首选材料。有必要开展进一步的研究，以评估分析物与局部健康或炎症状态之间的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Prosthetic Dentistry 医学-牙科与口腔外科

CiteScore

7.00

自引率

13.00%

发文量

599

审稿时长

69 days

期刊介绍： The Journal of Prosthetic Dentistry is the leading professional journal devoted exclusively to prosthetic and restorative dentistry. The Journal is the official publication for 24 leading U.S. international prosthodontic organizations. The monthly publication features timely, original peer-reviewed articles on the newest techniques, dental materials, and research findings. The Journal serves prosthodontists and dentists in advanced practice, and features color photos that illustrate many step-by-step procedures. The Journal of Prosthetic Dentistry is included in Index Medicus and CINAHL.