Impact of obesity in asthma: Possible future therapies

IF 6.2 2区 医学 Q1 ALLERGY
Hiroki Tashiro, Yuki Kurihara, Yuki Kuwahara, Koichiro Takahashi
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引用次数: 0

Abstract

Obesity is one of the factors associated with the severity of asthma. Obesity is associated with aggravation of the pathophysiology of asthma, including exacerbations, airway inflammation, decreased pulmonary function, and airway hyperresponsiveness. The present review addresses the characteristics of asthma with obesity, focusing especially on the heterogeneity caused by the degree of type 2 inflammation, sex differences, the onset of asthma, and race differences. To understand the severity mechanisms in asthma and obesity, such as corticosteroid resistance, fatty acids, gut microbiome, and cytokines, several basic research studies are evaluated. Finally, possible future therapies, including weight reduction, microbiome-targeted therapies, and other molecular targeted therapies are addressed. We believe that the present review will contribute to better understanding of the severity mechanisms and the establishment of novel treatments for severe asthma patients with obesity.

肥胖对哮喘的影响:未来可能的疗法
肥胖是与哮喘严重程度相关的因素之一。肥胖与哮喘的病理生理学恶化有关,包括病情加重、气道炎症、肺功能下降和气道高反应性。本综述探讨了肥胖性哮喘的特点,尤其关注 2 型炎症的程度、性别差异、哮喘发病时间和种族差异造成的异质性。为了了解哮喘和肥胖的严重性机制,如皮质类固醇抵抗、脂肪酸、肠道微生物组和细胞因子,本文对几项基础研究进行了评估。最后,还探讨了未来可能的疗法,包括减轻体重、微生物组靶向疗法和其他分子靶向疗法。我们相信,本综述将有助于更好地理解肥胖症严重性机制,并为肥胖症重症哮喘患者建立新的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Allergology International
Allergology International ALLERGY-IMMUNOLOGY
CiteScore
12.60
自引率
5.90%
发文量
96
审稿时长
29 weeks
期刊介绍: Allergology International is the official journal of the Japanese Society of Allergology and publishes original papers dealing with the etiology, diagnosis and treatment of allergic and related diseases. Papers may include the study of methods of controlling allergic reactions, human and animal models of hypersensitivity and other aspects of basic and applied clinical allergy in its broadest sense. The Journal aims to encourage the international exchange of results and encourages authors from all countries to submit papers in the following three categories: Original Articles, Review Articles, and Letters to the Editor.
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