Cranial Neural Crest Cells Contribution to Craniofacial Bone Development and Regeneration.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Osteoporosis Reports Pub Date : 2023-10-01 Epub Date: 2023-07-08 DOI:10.1007/s11914-023-00804-8

Piera Smeriglio, Antoine Zalc

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引用次数: 1

Abstract

Purpose of review: This review aims to summarize (i) the latest evidence on cranial neural crest cells (CNCC) contribution to craniofacial development and ossification; (ii) the recent discoveries on the mechanisms responsible for their plasticity; and (iii) the newest procedures to ameliorate maxillofacial tissue repair.

Recent findings: CNCC display a remarkable differentiation potential that exceeds the capacity of their germ layer of origin. The mechanisms by which they expand their plasticity was recently described. Their ability to participate to craniofacial bone development and regeneration open new perspectives for treatments of traumatic craniofacial injuries or congenital syndromes. These conditions can be life-threatening, require invasive maxillofacial surgery and can leave deep sequels on our health or quality of life. With accumulating evidence showing how CNCC-derived stem cells potential can ameliorate craniofacial reconstruction and tissue repair, we believe a deeper understanding of the mechanisms regulating CNCC plasticity is essential to ameliorate endogenous regeneration and improve tissue repair therapies.

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颅骨神经嵴细胞对颅面骨发育和再生的贡献。

综述目的：本综述旨在总结（i）颅神经嵴细胞（CNCC）对颅面发育和骨化的贡献的最新证据；（ii）关于其可塑性机制的最新发现；以及（iii）改善颌面组织修复的最新程序。最近的发现：CNCC表现出显著的分化潜力，超过了其起源胚层的能力。最近描述了它们扩大可塑性的机制。它们参与颅面骨发育和再生的能力为创伤性颅面损伤或先天性综合征的治疗开辟了新的前景。这些情况可能危及生命，需要进行侵入性颌面外科手术，并可能对我们的健康或生活质量造成严重影响。随着越来越多的证据表明CNCC衍生的干细胞潜力如何改善颅面重建和组织修复，我们相信，更深入地了解调节CNCC可塑性的机制对于改善内源性再生和改善组织修复疗法至关重要。

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来源期刊

Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

8.80

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.