Lipid metabolism in regulation of B cell development and autoimmunity

IF 9.3 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine & Growth Factor Reviews Pub Date : 2023-10-01 DOI:10.1016/j.cytogfr.2023.06.008

Xing Ji , Liang Wu , Tony Marion , Yubin Luo

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引用次数: 0

Abstract

B cells play an important role in adaptive immunity and participate in the process of humoral immunity mainly by secreting antibodies. The entire development and differentiation process of B cells occurs in multiple microenvironments and is regulated by a variety of environmental factors and immune signals. Differentiation biases or disfunction of B cells participate in the process of many autoimmune diseases. Emerging studies report the impact of altered metabolism in B cell biology, including lipid metabolism. Here, we discuss how extracellular lipid environment and metabolites, membrane lipid-related components, and lipid synthesis and catabolism programs coordinate B cell biology and describe the crosstalk of lipid metabolic programs with signal transduction pathways and transcription factors. We conclude with a summary of therapeutic targets for B cell lipid metabolism and signaling in autoimmune diseases and discuss important future directions.

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脂质代谢在调节B细胞发育和自身免疫中的作用。

B细胞在适应性免疫中起着重要作用，主要通过分泌抗体参与体液免疫过程。B细胞的整个发育和分化过程发生在多种微环境中，并受到各种环境因素和免疫信号的调节。B细胞的分化偏差或功能紊乱参与了许多自身免疫性疾病的过程。新兴的研究报告了B细胞生物学中代谢改变的影响，包括脂质代谢。在这里，我们讨论了细胞外脂质环境和代谢产物、膜脂质相关成分以及脂质合成和分解代谢程序如何协调B细胞生物学，并描述了脂质代谢程序与信号转导途径和转录因子的相互作用。最后，我们总结了自身免疫性疾病中B细胞脂质代谢和信号传导的治疗靶点，并讨论了未来的重要方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine & Growth Factor Reviews 生物-生化与分子生物学

CiteScore

21.10

自引率

1.50%

发文量

审稿时长

22 days

期刊介绍： Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.