{"title":"Modulation of gut microbiota with Ayurveda diet and lifestyle: A review on its possible way to treat type 2 diabetes.","authors":"Ashutosh Chauhan, Deepak Kumar Semwal, Ruchi Badoni Semwal, Sunil Kumar Joshi, Rajesh Kumar Adhana, Madhavi Sanjay Goswami","doi":"10.4103/ayu.AYU_7_20","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The prevalence of type 2 diabetes (T2D) has increased substantially in the past few decades throughout the world. In India, the epidemic of diabetes continues to increase irrespective of area, status, and age. Despite various scientific societies involved in the treatment of diabetes, still, the burden of diabetes keeps growing.</p><p><strong>Aims: </strong>The aim of this work is to explore the Ayurvedic concept of a personalized diet to modulate the gut microbiota for the treatment of T2D.</p><p><strong>Material and methods: </strong>A thorough study of literature from online scientific databases including Web of Science, PubMed, Scopus, and Google Scholar as well as from classical texts of Ayurveda was done. A careful compilation was done to extract the valuable output of the personalized diet to modulate the gut microbiota.</p><p><strong>Results: </strong>There are various diets used to control blood glucose levels, and their effects are also being studied on the transcriptome or epigenome despite 99.9% genomic similarity among human beings. However, microbiomes have only 10% similarity. Ayurvedic diet is given on the basis of <i>Prakriti</i> (body constitution), therefore, it is also called personalized diet.</p><p><strong>Conclusion: </strong>The diets prescribed for T2D in Ayurveda are high in fibers, polyphenols, and complex carbohydrates which enrich butyrate-producing bacteria and decrease lipopolysaccharide-producing bacteria. Hence, there is a need to have a personalized diet to manage the glucose level by enriching beneficial gut microbiota. The approach of a personalized diet associated with gut microbiota can be helpful in maintaining blood sugar in T2D patients.</p>","PeriodicalId":8720,"journal":{"name":"Ayu","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c1/f9/AYU-43-35.PMC10468021.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ayu","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ayu.AYU_7_20","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/2 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The prevalence of type 2 diabetes (T2D) has increased substantially in the past few decades throughout the world. In India, the epidemic of diabetes continues to increase irrespective of area, status, and age. Despite various scientific societies involved in the treatment of diabetes, still, the burden of diabetes keeps growing.
Aims: The aim of this work is to explore the Ayurvedic concept of a personalized diet to modulate the gut microbiota for the treatment of T2D.
Material and methods: A thorough study of literature from online scientific databases including Web of Science, PubMed, Scopus, and Google Scholar as well as from classical texts of Ayurveda was done. A careful compilation was done to extract the valuable output of the personalized diet to modulate the gut microbiota.
Results: There are various diets used to control blood glucose levels, and their effects are also being studied on the transcriptome or epigenome despite 99.9% genomic similarity among human beings. However, microbiomes have only 10% similarity. Ayurvedic diet is given on the basis of Prakriti (body constitution), therefore, it is also called personalized diet.
Conclusion: The diets prescribed for T2D in Ayurveda are high in fibers, polyphenols, and complex carbohydrates which enrich butyrate-producing bacteria and decrease lipopolysaccharide-producing bacteria. Hence, there is a need to have a personalized diet to manage the glucose level by enriching beneficial gut microbiota. The approach of a personalized diet associated with gut microbiota can be helpful in maintaining blood sugar in T2D patients.
背景:在过去的几十年里,世界各地2型糖尿病(T2D)的患病率大幅上升。在印度,无论地区、地位和年龄如何,糖尿病的流行都在继续增加。尽管各种科学团体都参与了糖尿病的治疗,但糖尿病的负担仍然在不断增加。目的:这项工作的目的是探索阿育吠陀的个性化饮食概念,以调节肠道微生物群来治疗T2D。材料和方法:对来自在线科学数据库(包括Web of Science、PubMed、Scopus和Google Scholar)以及阿育吠达经典文本的文献进行了彻底研究。我们进行了仔细的汇编,以提取个性化饮食的宝贵输出,从而调节肠道微生物群。结果:有各种饮食用于控制血糖水平,尽管人类之间有99.9%的基因组相似性,但它们对转录组或表观基因组的影响也在研究中。然而,微生物组只有10%的相似性。阿育吠陀饮食是在Prakriti(身体构造)的基础上提供的,因此,它也被称为个性化饮食。结论:阿育吠陀T2D饮食富含纤维、多酚和复合碳水化合物,可丰富丁酸产生菌,减少脂多糖产生菌。因此,需要有一种个性化的饮食,通过丰富有益的肠道微生物群来控制葡萄糖水平。与肠道微生物群相关的个性化饮食方法有助于维持T2D患者的血糖。