The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory-Shigella spp.

IF 0.5 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Applied Biosafety Pub Date : 2023-06-01 DOI:10.1089/apb.2022.0046

Stuart D Blacksell, Sandhya Dhawan, Marina Kusumoto, Kim Khanh Le, Ben J Davis, Kathrin Summermatter, Joseph O'Keefe, Joseph Kozlovac, Salama Suhail Almuhairi, Indrawati Sendow, Christina M Scheel, Anthony Ahumibe, Zibusiso M Masuku, Allan M Bennett, Kazunobu Kojima, David R Harper, Keith Hamilton

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引用次数: 0

Abstract

Introduction: Shigella bacteria cause shigellosis, a gastrointestinal infection most often acquired from contaminated food or water.

Methods: In this review, the general characteristics of Shigella bacteria are described, cases of laboratory-acquired infections (LAIs) are discussed, and evidence gaps in current biosafety practices are identified.

Results: LAIs are undoubtedly under-reported. Owing to the low infectious dose, rigorous biosafety level 2 practices are required to prevent LAIs resulting from sample manipulation or contact with infected surfaces.

Conclusions: It is recommended that, before laboratory work with Shigella, an evidence-based risk assessment be conducted. Particular emphasis should be placed on personal protective equipment, handwashing, and containment practices for procedures that generate aerosols or droplets.

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生物安全研究路线图:寻找支持实验室实践的证据-志贺氏菌。

简介:志贺氏菌引起志贺氏菌病，这是一种胃肠道感染，最常通过受污染的食物或水获得。方法:本文综述了志贺氏菌的一般特征，讨论了实验室获得性感染(LAIs)的病例，并确定了当前生物安全实践中的证据差距。结果:LAIs无疑是少报的。由于感染剂量低，需要采取严格的2级生物安全措施，以防止因样品操作或接触受感染表面而造成的lai。结论:建议在开展志贺氏菌的实验室工作之前，进行基于证据的风险评估。应特别强调个人防护装备、洗手和产生气溶胶或液滴的程序的密封措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Biosafety Environmental Science-Management, Monitoring, Policy and Law

CiteScore

2.50

自引率

13.30%

发文量

期刊介绍： Applied Biosafety (APB), sponsored by ABSA International, is a peer-reviewed, scientific journal committed to promoting global biosafety awareness and best practices to prevent occupational exposures and adverse environmental impacts related to biohazardous releases. APB provides a forum for exchanging sound biosafety and biosecurity initiatives by publishing original articles, review articles, letters to the editors, commentaries, and brief reviews. APB informs scientists, safety professionals, policymakers, engineers, architects, and governmental organizations. The journal is committed to publishing on topics significant in well-resourced countries as well as information relevant to underserved regions, engaging and cultivating the development of biosafety professionals globally.