Novel metal nanomaterials to promote angiogenesis in tissue regeneration

Q1 Medicine

Engineered regeneration Pub Date : 2023-09-01 DOI:10.1016/j.engreg.2023.03.008

Yuki G. Yoshida , Su Yan , Hui Xu , Jian Yang

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引用次数: 5

Abstract

Angiogenesis—the formation of new blood vessels from existing blood vessels—has drawn significant attention in medical research. New techniques have been developed to control proangiogenic factors to obtain desired effects. Two important research areas are 1) understanding cellular mechanisms and signaling pathways involved in angiogenesis and 2) discovering new biomaterials and nanomaterials with proangiogenic effects. This paper reviews recent developments in controlling angiogenesis in the context of regenerative medicine and wound healing. We focus on novel proangiogenic materials that will advance the field of regenerative medicine. Specifically, we mainly focus on metal nanomaterials. We also discuss novel technologies developed to carry these proangiogenic inorganic molecules efficiently to target sites. We offer a comprehensive overview by combining existing knowledge regarding metal nanomaterials with novel developments that are still being refined to identify new nanomaterials.

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新型金属纳米材料促进组织再生血管生成

血管生成——从现有血管中形成新血管——在医学研究中引起了极大的关注。新技术的发展，以控制促血管生成因子，以获得预期的效果。两个重要的研究领域是:1)了解血管生成的细胞机制和信号通路;2)发现具有促进血管生成作用的新型生物材料和纳米材料。本文综述了在再生医学和伤口愈合的背景下控制血管生成的最新进展。我们专注于将推动再生医学领域的新型促血管生成材料。具体来说，我们主要关注的是金属纳米材料。我们还讨论了将这些促进血管生成的无机分子有效地运送到靶点的新技术。我们提供了一个全面的概述，结合现有的知识，有关金属纳米材料的新发展，仍在完善，以确定新的纳米材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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