tRNA-derived RNAs: Biogenesis and roles in translational control.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY
Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-11-01 Epub Date: 2023-07-05 DOI:10.1002/wrna.1805
Yasutoshi Akiyama, Pavel Ivanov
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引用次数: 0

Abstract

Transfer RNA (tRNA)-derived RNAs (tDRs) are a class of small non-coding RNAs that play important roles in different aspects of gene expression. These ubiquitous and heterogenous RNAs, which vary across different species and cell types, are proposed to regulate various biological processes. In this review, we will discuss aspects of their biogenesis, and specifically, their contribution into translational control. We will summarize diverse roles of tDRs and the molecular mechanisms underlying their functions in the regulation of protein synthesis and their impact on related events such as stress-induced translational reprogramming. This article is categorized under: RNA Processing > Processing of Small RNAs Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs Regulatory RNAs/RNAi/Riboswitches > Biogenesis of Effector Small RNAs.

Abstract Image

trna衍生的rna:生物发生及其在翻译控制中的作用。
tRNA衍生RNA (Transfer RNA -derived RNAs, tDRs)是一类小分子非编码RNA,在基因表达的不同方面发挥重要作用。这些普遍存在的异质rna在不同的物种和细胞类型中存在差异,被认为可以调节各种生物过程。在这篇综述中,我们将讨论它们的生物发生方面,特别是它们在翻译控制中的贡献。我们将总结tdr的不同作用及其在蛋白质合成调控中的分子机制,以及它们对应激诱导的翻译重编程等相关事件的影响。本文分为:RNA加工>小RNA加工调控RNA /RNAi/Riboswitches >调控RNA调控RNA /RNAi/Riboswitches >效应小RNA的生物发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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