The spatiotemporal control of ER membrane fragmentation during reticulophagy.

IF 14.6 1区 生物学 Q1 CELL BIOLOGY
Autophagy Pub Date : 2024-01-01 Epub Date: 2023-08-31 DOI:10.1080/15548627.2023.2252723
Xinyi Wang, Boran Li, Qiming Sun
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引用次数: 0

Abstract

Reticulophagy is an evolutionarily conserved mechanism essential to maintain the endoplasmic reticulum (ER) homeostasis. A series of studies identified a panel of reticulophagy receptors. However, it remains unclear how these receptors sense upstream signals for spatiotemporal control of reticulophagy and how ER is fragmented into small pieces for sequestration into phagophores. Recently, we and others showed that the oligomerization of RETREG1/FAM134B (reticulophagy regulator 1), an reticulophagy receptor, triggers the scission of ER membrane to facilitate reticulophagy. Furthermore, we demonstrated that upstream signals are transduced by sequential phosphorylation and acetylation of RETREG1, which stimulate its oligomerization, ER fragmentation and reticulophagy. Our work provides further mechanistic insights into how reticulophagy receptor conveys cellular signals to fine-tune of ER homeostasis.Abbreviations: ER, endoplasmic reticulum; MAP1LC3, microtubule-associated protein light chain 3; RETREG1, reticulophagy regulator 1; RHD, reticulon-homology domain.

网状吞噬过程中ER膜破碎的时空控制
网状吞噬是一种进化保守的机制,对维持内质网(ER)的平衡至关重要。一系列研究发现了一系列网状吞噬受体。然而,目前仍不清楚这些受体如何感知上游信号以控制网吞噬的时空,也不清楚内质网如何被分割成小块以固着在吞噬细胞中。最近,我们和其他人发现,网吞噬受体 RETREG1/FAM134B(网吞噬调节因子 1)的寡聚化引发了 ER 膜的裂解,从而促进了网吞噬。此外,我们还证明了上游信号是通过 RETREG1 的连续磷酸化和乙酰化传递的,从而刺激其寡聚化、ER 断裂和网状吞噬。我们的工作为网状吞噬受体如何传递细胞信号以微调ER平衡提供了进一步的机理见解:缩写:ER,内质网;MAP1LC3,微管相关蛋白轻链 3;RETREG1,网吞噬调节因子 1;RHD,网吞噬同源结构域。
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来源期刊
Autophagy
Autophagy 生物-细胞生物学
CiteScore
21.30
自引率
2.30%
发文量
277
审稿时长
1 months
期刊介绍: Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.
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