{"title":"Sex is predicted by spatial memory multivariate activation patterns.","authors":"Dylan S Spets, Scott D Slotnick","doi":"10.1101/lm.053608.122","DOIUrl":null,"url":null,"abstract":"<p><p>Whether sex differences exist in the brain at the macroscopic level, as measured with magnetic resonance imaging (MRI), is a topic of debate. The present spatial long-term memory functional MRI (fMRI) study predicted sex based on event-related patterns of brain activity. Within spatial memory regions of interest, patterns of activity associated with females and males were used to predict the sex of each member of left-out female-male pairs at above-chance accuracy. The current results provide evidence for sex differences in the brain processes underlying spatial long-term memory. This is the first time that sex has been predicted using event-related fMRI activation patterns. The present findings contribute to a growing body of evidence that there are functional and anatomic sex differences in the brain and, more broadly, question the widespread practice of collapsing across sex in the field of cognitive neuroscience.</p>","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a1/fe/LM053608Spe.PMC9488029.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Learning & memory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1101/lm.053608.122","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Whether sex differences exist in the brain at the macroscopic level, as measured with magnetic resonance imaging (MRI), is a topic of debate. The present spatial long-term memory functional MRI (fMRI) study predicted sex based on event-related patterns of brain activity. Within spatial memory regions of interest, patterns of activity associated with females and males were used to predict the sex of each member of left-out female-male pairs at above-chance accuracy. The current results provide evidence for sex differences in the brain processes underlying spatial long-term memory. This is the first time that sex has been predicted using event-related fMRI activation patterns. The present findings contribute to a growing body of evidence that there are functional and anatomic sex differences in the brain and, more broadly, question the widespread practice of collapsing across sex in the field of cognitive neuroscience.
期刊介绍：
The neurobiology of learning and memory is entering a new interdisciplinary era. Advances in neuropsychology have identified regions of brain tissue that are critical for certain types of function. Electrophysiological techniques have revealed behavioral correlates of neuronal activity. Studies of synaptic plasticity suggest that some mechanisms of memory formation may resemble those of neural development. And molecular approaches have identified genes with patterns of expression that influence behavior. It is clear that future progress depends on interdisciplinary investigations. The current literature of learning and memory is large but fragmented. Until now, there has been no single journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Learning & Memory provides a forum for these investigations in the form of research papers and review articles.
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