A flexible implant for acute intrapancreatic electrophysiology

IF 3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Biomedical Microdevices Pub Date : 2023-08-30 DOI:10.1007/s10544-023-00662-2

Domenic Pascual, Lisa Brauns, Ruth Domes, Matthias Tisler, Marco Kögel, Angelika Stumpf, Andreas Kirschniak, Jens Rolinger, Udo Kraushaar, Peter D. Jones

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Abstract

Microelectrode arrays (MEAs) have proven to be a powerful tool to study electrophysiological processes over the last decades with most technology developed for investigation of the heart or brain. Other targets in the field of bioelectronic medicine are the peripheral nervous system and its innervation of various organs. Beyond the heart and nervous systems, the beta cells of the pancreatic islets of Langerhans generate action potentials during the production of insulin. In vitro experiments have demonstrated that their activity is a biomarker for blood glucose levels, suggesting that recording their activity in vivo could support patients suffering from diabetes mellitus with long-term automated read-out of blood glucose concentrations. Here, we present a flexible polymer-based implant having 64 low impedance microelectrodes designed to be implanted to a depth of 10 mm into the pancreas. As a first step, the implant will be used in acute experiments in pigs to explore the electrophysiological processes of the pancreas in vivo. Beyond use in the pancreas, our flexible implant and simple implantation method may also be used in other organs such as the brain.

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一种用于急性胰腺内电生理的柔性植入物。

在过去的几十年里，微电极阵列（MEA）已被证明是研究电生理过程的强大工具，大多数技术都是为研究心脏或大脑而开发的。生物电子医学领域的其他靶点是外周神经系统及其各种器官的神经支配。除了心脏和神经系统，郎格罕胰岛的β细胞在产生胰岛素的过程中产生动作电位。体外实验表明，它们的活性是血糖水平的生物标志物，这表明在体内记录它们的活性可以通过长期自动读取血糖浓度来支持糖尿病患者。在这里，我们提出了一种具有64个低阻抗微电极的柔性聚合物基植入物，该微电极被设计成植入胰腺10mm的深度。作为第一步，该植入物将用于猪的急性实验，以探索胰腺在体内的电生理过程。除了在胰腺中使用，我们的柔性植入物和简单的植入方法也可以用于其他器官，如大脑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Microdevices 工程技术-工程：生物医学

CiteScore

6.90

自引率

3.60%

发文量

审稿时长

6 months

期刊介绍： Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.