Recent targets of osteoarthritis research

IF 4.5 2区医学 Q1 RHEUMATOLOGY

Best Practice & Research in Clinical Rheumatology Pub Date : 2023-06-01 DOI:10.1016/j.berh.2023.101851

Po-Cheng Shih , Yung-Heng Lee , Hsi-Kai Tsou , James Cheng-Chung Wei

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引用次数: 0

Abstract

Osteoarthritis is one of the most common diseases and poses a significant medical burden worldwide. Currently, the diagnosis and treatment of osteoarthritis primarily rely on clinical symptoms and changes observed in radiographs or other image modalities. However, identification based on reliable biomarkers would greatly improve early diagnosis, help with precise monitoring of disease progression, and provide aid for accurate treatment. In recent years, several biomarkers for osteoarthritis have been identified, including image modalities and biochemical biomarkers such as collagen degradation products, pro- or anti-inflammatory cytokines, micro RNAs, long non-coding RNAs, and circular RNAs. These biomarkers offer new insights in the pathogenesis of osteoarthritis and provide potential targets for further research. This article reviews the evolution of osteoarthritis biomarkers from the perspective of pathogenesis and emphasizes the importance of continued research to improve the diagnosis, treatment, and management of osteoarthritis.

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骨关节炎研究的最新目标。

骨关节炎是最常见的疾病之一，给全世界带来了沉重的医疗负担。目前，骨关节炎的诊断和治疗主要依赖于临床症状和在 X 光片或其他影像模式中观察到的变化。然而，基于可靠生物标志物的鉴定将大大提高早期诊断率，有助于精确监测疾病进展，并为准确治疗提供帮助。近年来，骨关节炎的一些生物标志物已被确定，包括图像模式和生化生物标志物，如胶原降解产物、促炎或抗炎细胞因子、微小 RNA、长非编码 RNA 和环状 RNA。这些生物标志物为骨关节炎的发病机制提供了新的见解，并为进一步研究提供了潜在的目标。本文从发病机制的角度回顾了骨关节炎生物标志物的演变，并强调了持续研究对改善骨关节炎诊断、治疗和管理的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research in Clinical Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

0.00%

发文量

审稿时长

27 days

期刊介绍： Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.