Measuring Antisocial Behaviors in Behavioral Variant Frontotemporal Dementia With a Novel Informant-Based Questionnaire.

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2023-01-01 Epub Date: 2023-07-07 DOI:10.1176/appi.neuropsych.20220135

Tony X Phan, Jerica E Reeder, Lindsey C Keener, Ciaran M Considine, David H Zald, Daniel O Claassen, R Ryan Darby

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Abstract

Objective: Antisocial behaviors are common and problematic among patients with behavioral variant frontotemporal dementia (bvFTD). In the present study, the investigators aimed to validate an informant-based questionnaire developed to measure the extent and severity of antisocial behaviors among patients with dementia.

Methods: The Social Behavior Questionnaire (SBQ) was developed to measure 26 antisocial behaviors on a scale from absent (0) to very severe (5). It was administered to 23 patients with bvFTD, 19 patients with Alzheimer's disease, and 14 patients with other frontotemporal lobar degeneration syndromes. Group-level differences in the presence and severity of antisocial behaviors were measured. Psychometric properties of the SBQ were assessed by using Cronbach's alpha, exploratory factor analysis, and comparisons with a psychopathy questionnaire. Cluster analysis was used to determine whether the SBQ identifies different subgroups of patients.

Results: Antisocial behaviors identified by using the SBQ were common and severe among patients with bvFTD, with at least one such behavior endorsed for 21 of 23 (91%) patients. Antisocial behaviors were more severe among patients with bvFTD, including the subsets of patients with milder cognitive impairment and milder disease severity, than among patients in the other groups. The SBQ was internally consistent (Cronbach's α=0.81). Exploratory factor analysis supported separate factors for aggressive and nonaggressive behaviors. Among the patients with bvFTD, the factor scores for aggressive behavior on the SBQ were correlated with those for antisocial behavior measured on the psychopathy scale, but the nonaggressive scores were not correlated with psychopathy scale measures. The k-means clustering analysis identified a subset of patients with severe antisocial behaviors.

Conclusions: The SBQ is a useful tool to identify, characterize, and measure the severity of antisocial behaviors among patients with dementia.

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用一种新的基于信息者的问卷测量行为变异性额颞叶痴呆患者的反社会行为。

目的：行为变异性额颞叶痴呆（bvFTD）患者的反社会行为是常见的，也是有问题的。在本研究中，研究人员旨在验证一份基于线人的问卷，该问卷旨在衡量痴呆症患者反社会行为的程度和严重程度。方法：采用社会行为问卷（SBQ）对26种反社会行为进行测量，从缺席（0）到非常严重（5）。23名bvFTD患者、19名阿尔茨海默病患者和14名其他额颞叶变性综合征患者服用了该药物。测量了反社会行为的存在和严重程度的群体水平差异。SBQ的心理测量特性通过使用Cronbachα、探索性因素分析以及与精神病问卷的比较进行评估。聚类分析用于确定SBQ是否识别不同的患者亚组。结果：使用SBQ确定的反社会行为在bvFTD患者中是常见和严重的，23名患者中有21名（91%）患者至少有一种反社会行为得到认可。bvFTD患者的反社会行为比其他组的患者更严重，包括认知障碍较轻和疾病严重程度较轻的患者亚群。SBQ内部一致（Cronbachα=0.81）。探索性因素分析支持攻击性和非攻击性行为的独立因素。在bvFTD患者中，SBQ中攻击性行为的因素得分与精神病量表中反社会行为的因素评分相关，但非攻击性得分与精神疾病量表中的因素得分不相关。k-means聚类分析确定了一组有严重反社会行为的患者。结论：SBQ是识别、表征和衡量痴呆患者反社会行为严重程度的有用工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuropsychiatry and Clinical Neurosciences 医学-精神病学

CiteScore

5.30

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： As the official Journal of the American Neuropsychiatric Association, the premier North American organization of clinicians, scientists, and educators specializing in behavioral neurology & neuropsychiatry, neuropsychology, and the clinical neurosciences, the Journal of Neuropsychiatry and Clinical Neurosciences (JNCN) aims to publish works that advance the science of brain-behavior relationships, the care of persons and families affected by neurodevelopmental, acquired neurological, and neurodegenerative conditions, and education and training in behavioral neurology & neuropsychiatry. JNCN publishes peer-reviewed articles on the cognitive, emotional, and behavioral manifestations of neurological conditions, the structural and functional neuroanatomy of idiopathic psychiatric disorders, and the clinical and educational applications and public health implications of scientific advances in these areas. The Journal features systematic reviews and meta-analyses, narrative reviews, original research articles, scholarly considerations of treatment and educational challenges in behavioral neurology & neuropsychiatry, analyses and commentaries on advances and emerging trends in the field, international perspectives on neuropsychiatry, opinions and introspections, case reports that inform on the structural and functional bases of neuropsychiatric conditions, and classic pieces from the field’s rich history.