Amber T Wolf, Janek Klawe, Bian Liu, Sumayya Ahmad
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引用次数: 0
Abstract
Purpose: To assess the relationship between serum vitamin D levels and myopia in people aged 12-50 years using the National Health and Nutrition Examination Survey (NHANES) database.
Methods: Demographics, vision, and serum vitamin D levels from NHANES (2001-2006) were analyzed. Multivariate analyses were performed to examine the relationship between serum vitamin D levels and myopia while controlling for sex, age, ethnicity, education level, serum vitamin A, and poverty status. The main outcome was presence or absence of myopia, defined as a spherical equivalent of -1 diopters or more.
Results: Of the 11669 participants, 5,310 (45.5%) had myopia. The average serum vitamin D concentration was 61.6 ± 0.9 nmol/L for the myopic group and 63.1 ± 0.8 nmol/L for the non-myopic group (p = .01). After adjusting for all covariates, having higher serum vitamin D was associated with lower odds of having myopia (odds ratio 0.82 [0.74-0.92], p = .0007). In linear regression modeling that excluded hyperopes (spherical equivalent > +1 diopters), there was a positive relationship between spherical equivalent and serum vitamin D levels. Specifically, as serum vitamin D doubled, spherical equivalent increased by 0.17 (p = .02) indicating a positive dose-response relationship between vitamin D and myopia.
Conclusions: Participants with myopia, on average, had lower serum concentrations of vitamin D compared to those without myopia. While further studies are needed to determine the mechanism, this study suggests that higher vitamin D levels are associated with lower incidence of myopia.
目的：利用美国国家健康与营养调查（NHANES）数据库，评估 12-50 岁人群血清维生素 D 水平与近视之间的关系：分析了 NHANES（2001-2006 年）的人口统计学、视力和血清维生素 D 水平。在控制性别、年龄、种族、教育水平、血清维生素 A 和贫困状况的情况下，进行了多变量分析，以研究血清维生素 D 水平与近视之间的关系。主要结果是有无近视，近视的定义是球面等效度数为-1 或以上：在 11669 名参与者中，5310 人（45.5%）患有近视。近视组的平均血清维生素 D 浓度为 61.6 ± 0.9 nmol/L，非近视组的平均血清维生素 D 浓度为 63.1 ± 0.8 nmol/L（p = .01）。在对所有协变量进行调整后，血清维生素 D 含量越高，患近视的几率越低（几率比 0.82 [0.74-0.92]，p = 0.0007）。在排除远视眼（球面等效 > +1 斜度）的线性回归模型中，球面等效与血清维生素 D 水平之间存在正相关关系。具体来说，当血清维生素 D 增加一倍时，球面等效度增加 0.17 (p = .02)，这表明维生素 D 与近视之间存在正剂量反应关系：结论：与没有近视的人相比，患有近视的参与者血清中维生素 D 的浓度平均较低。虽然还需要进一步研究来确定其机制，但本研究表明，维生素 D 水平越高，近视的发病率越低。
期刊介绍：
Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.
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