Effects of intake of Lactococcus cremoris subsp. cremoris FC on constipation symptoms and immune system in healthy participants with mild constipation: a double-blind, placebo-controlled study.

IF 3.5 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY
Masamichi Watanabe, Toshinari Maruo, Toshio Suzuki
{"title":"Effects of intake of <i>Lactococcus cremoris</i> subsp. <i>cremoris</i> FC on constipation symptoms and immune system in healthy participants with mild constipation: a double-blind, placebo-controlled study.","authors":"Masamichi Watanabe,&nbsp;Toshinari Maruo,&nbsp;Toshio Suzuki","doi":"10.1080/09637486.2023.2236805","DOIUrl":null,"url":null,"abstract":"<p><p>This study evaluated the effect of <i>Lactococcus cremoris</i> subsp. <i>cremoris</i> FC (FC) on constipation symptoms and the immune system in healthy participants with mild constipation. Eighty-three participants were randomised into four groups with different doses: 50, 75, and 100 mg of freeze-dried FC (test) or corn starch (placebo). Defaecation frequency significantly increased in all test groups compared to the placebo group. Stool appearance and volume were improved considerably within the groups administered 50 mg and 75 mg of FC. The abundances of total bacteria, <i>Bifidobacterium</i> spp., and <i>Lactobacillus</i> group in the faeces showed increasing trends in the test groups. Regarding immunological parameters, the naive T cell counts in the blood were significantly higher at a dose of 75 mg of FC in the test group than in the placebo group. These results suggest that FC intake improves defaecation and some immunological parameters, especially naive T cell counts, in healthy adults.</p>","PeriodicalId":14087,"journal":{"name":"International Journal of Food Sciences and Nutrition","volume":"74 6","pages":"695-706"},"PeriodicalIF":3.5000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Food Sciences and Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1080/09637486.2023.2236805","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

This study evaluated the effect of Lactococcus cremoris subsp. cremoris FC (FC) on constipation symptoms and the immune system in healthy participants with mild constipation. Eighty-three participants were randomised into four groups with different doses: 50, 75, and 100 mg of freeze-dried FC (test) or corn starch (placebo). Defaecation frequency significantly increased in all test groups compared to the placebo group. Stool appearance and volume were improved considerably within the groups administered 50 mg and 75 mg of FC. The abundances of total bacteria, Bifidobacterium spp., and Lactobacillus group in the faeces showed increasing trends in the test groups. Regarding immunological parameters, the naive T cell counts in the blood were significantly higher at a dose of 75 mg of FC in the test group than in the placebo group. These results suggest that FC intake improves defaecation and some immunological parameters, especially naive T cell counts, in healthy adults.

摄食乳酸菌亚种的影响。cremoris FC对轻度便秘健康参与者便秘症状和免疫系统的影响:一项双盲、安慰剂对照研究
本研究评估了乳酸菌亚种的作用。cremoris FC (FC)对轻度便秘健康参与者便秘症状和免疫系统的影响。83名参与者被随机分为四组,剂量不同:50、75和100毫克冻干FC(测试)或玉米淀粉(安慰剂)。与安慰剂组相比,所有试验组的排便频率都显著增加。在给予50 mg和75 mg FC的组中,粪便外观和体积显着改善。各试验组粪便中总细菌、双歧杆菌和乳杆菌群的丰度均呈增加趋势。在免疫参数方面,试验组在75 mg FC剂量下血液中的幼稚T细胞计数明显高于安慰剂组。这些结果表明,摄入FC可以改善健康成人的排便和一些免疫参数,特别是幼稚T细胞计数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
7.50
自引率
2.60%
发文量
60
审稿时长
1 months
期刊介绍: The primary aim of International Journal of Food Sciences and Nutrition is to integrate food science with nutrition. Improvement of knowledge in human nutrition should always be the final objective of submitted research. It''s an international, peer-reviewed journal which publishes high quality, original research contributions to scientific knowledge. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信