Pigmentation of lower limbs: Contribution of haemosiderin and melanin in chronic venous insufficiency and related disorders.

IF 1.6 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Phlebology Pub Date : 2023-12-01 Epub Date: 2023-08-29 DOI:10.1177/02683555231196702

Lois Zhang, Kate Ng, James P Pham, Samuel Thoo, Anes Yang, Mina Kang, David Connor, Steven Kossard, Kurosh Parsi

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引用次数: 0

Abstract

Background: To determine the composition of skin pigmentation in chronic venous insufficiency (CVI) and other less common vascular conditions of lower limbs.

Methods: Forty-five skin biopsies were obtained from 17 patients. Samples were taken from pigmented regions and compared with control non-lesional samples from the same patient. Perl's Prussian Blue was used to identify haemosiderin and Schmorl's for melanin.

Results: Seven patients presented with CVI, one with concurrent livedo vasculopathy (LV). One patient had LV only. Two patients had acroangiodermatitis (AAD). Six patients had post-sclerotherapy pigmentation (PSP), one with concurrent post-inflammatory hyperpigmentation (PIH). One patient had PIH only. The predominant pigment in CVI samples was haemosiderin. C5-C6 patients showed increased epidermal melanin. LV, AAD, and PSP samples showed dermal haemosiderin but no increase in epidermal melanin. PIH samples showed prominent epidermal melanin whilst no haemosiderin was detected.

Conclusion: The predominant pigment in CVI and other vascular conditions was haemosiderin. Melanin was present in later stages of CVI (C5-C6) and in PIH.

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下肢色素沉着:血黄素和黑色素在慢性静脉功能不全及相关疾病中的作用。

背景:探讨慢性静脉功能不全(CVI)及其他下肢少见血管疾病患者皮肤色素沉着的组成。方法:对17例患者行45例皮肤活检。样本取自色素沉着区，并与来自同一患者的对照非病变样本进行比较。珀尔普鲁士蓝用于鉴定血黄素，施莫尔蓝用于鉴定黑色素。结果:7例患者出现CVI, 1例并发活体血管病变(LV)。1例患者仅为左室。2例患者有肢端血管皮炎(AAD)。6例患者有硬化治疗后色素沉着(PSP)， 1例并发炎症后色素沉着(PIH)。1例患者仅患有PIH。CVI样品中的主要色素为血黄素。C5-C6患者表皮黑色素升高。LV, AAD和PSP样品显示真皮血黄素，但表皮黑色素未增加。PIH样品表皮黑色素明显，未检出血黄素。结论:CVI及其他血管病变的主要色素为血黄素。黑色素存在于CVI晚期(C5-C6)和PIH。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phlebology 医学-外周血管病

CiteScore

3.30

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The leading scientific journal devoted entirely to venous disease, Phlebology is the official journal of several international societies devoted to the subject. It publishes the results of high quality studies and reviews on any factor that may influence the outcome of patients with venous disease. This journal provides authoritative information about all aspects of diseases of the veins including up to the minute reviews, original articles, and short reports on the latest treatment procedures and patient outcomes to help medical practitioners, allied health professionals and scientists stay up-to-date on developments. Print ISSN: 0268-3555