Paracrine regulation of granulosa cell development in the antral follicles in mammals.

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2023-08-26 eCollection Date: 2023-01-01 DOI:10.1002/rmb2.12538

Koji Sugiura, Natsumi Maruyama, Yuki Akimoto, Kodai Matsushita, Tsutomu Endo

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Abstract

Background: Development of ovarian follicles is regulated by a complex interaction of intra- and extra-follicular signals. Oocyte-derived paracrine factors (ODPFs) play a central role in this process in cooperation with other signals.

Methods: This review provides an overview of the recent advances in our understanding of the paracrine regulation of antral follicle development in mammals. It specifically focuses on the regulation of granulosa cell development by ODPFs, along with other intrafollicular signals.

Main findings: Bi-directional communication between oocytes and surrounding cumulus cells is a fundamental mechanism that determines cumulus cell differentiation. Along with estrogen, ODPFs promote the expression of forkhead box L2, a critical transcription factor required for mural granulosa cells. Follicle-stimulating hormone (FSH) facilitates these processes by stimulating estrogen production in mural granulosa cells.

Conclusion: Cooperative interactions among ODPFs, FSH, and estrogen are critical in determining the fate of cumulus and mural granulosa cells, as well as the development of oocytes.

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哺乳动物中腔卵泡颗粒细胞发育的旁分泌调节。

背景：卵泡的发育受到卵泡内和卵泡外信号的复杂相互作用的调节。卵母细胞衍生的旁分泌因子（ODPFs）与其他信号协同在这一过程中发挥着核心作用。方法：本文综述了近年来我们对哺乳动物窦卵泡发育的旁分泌调节的理解进展。它特别关注ODPF以及其他卵泡内信号对颗粒细胞发育的调节。主要发现：卵母细胞和周围卵丘细胞之间的双向通讯是决定卵丘细胞分化的基本机制。ODPFs与雌激素一起促进叉头盒L2的表达，叉头盒是壁颗粒细胞所需的关键转录因子。卵泡刺激素（FSH）通过刺激壁颗粒细胞中雌激素的产生来促进这些过程。结论：ODPFs、FSH和雌激素之间的协同作用对决定卵丘和壁颗粒细胞的命运以及卵母细胞的发育至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.