Interleukin 17A and 17F polymorphisms and asthma susceptibility: Correspondence

IF 2.3 4区医学 Q3 GENETICS & HEREDITY

International Journal of Immunogenetics Pub Date : 2023-02-13 DOI:10.1111/iji.12615

Amnuay Kleebayoon, Viroj Wiwanitkit

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引用次数: 0

Abstract

Dear Editor, we would like to share ideas on the publication ‘Associations between interleukin 17A and 17F polymorphisms and asthma susceptibility: A meta-analysis’ (Lee & Song, 2023). Lee and Song looked for publications reporting IL17 polymorphisms in asthma patients and healthy controls using the PubMed/Medline and Embase databases (Lee & Song, 2023). Asthma susceptibility was studied using meta-analyses to examine the relationships between IL17Ars8193036 (−737C/T), rs2275913 (−197G/A), rs3819024 (A/G), rs3748067 (C/T), and rs4711998 (A/G) polymorphisms and (Lee & Song, 2023) IL17F rs763780 (7488A/G). According to Lee and Song, no correlation between this polymorphism and asthma could be established utilizing the allele contrast, dominant, or homozygous contrast models. In this meta-analysis, no proof of a relationship between any other IL17A and IL17F polymorphism and asthma susceptibility was discovered (Lee & Song, 2023). Finally, Lee and Song found that only the CC genotype of the IL17A rs8193036 polymorphism is linked to asthma susceptibility (Lee & Song, 2023). In this study, the impact of a polymorphism is examined. The hereditary factor discussed in this article might or might not have an effect. We both agree that the targeted observation might be related to the investigated underlying genetic component. However, a variety of genetic variants have been connected to the levels of serum folate, cobalamin, and homocysteine. Examples include NLRP3, MAVS, and GSDM gene polymorphisms (Imraish et al., 2022; Xulong et al., 2022). Future research should concentrate on the effects of unexpected, maybe confounding genetic variations. Amnuay Kleebayoon1 VirojWiwanitkit2

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白细胞介素17A和17F多态性与哮喘易感性:对应关系

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来源期刊

International Journal of Immunogenetics 医学-免疫学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Immunogenetics (formerly European Journal of Immunogenetics) publishes original contributions on the genetic control of components of the immune system and their interactions in both humans and experimental animals. The term ''genetic'' is taken in its broadest sense to include studies at the evolutionary, molecular, chromosomal functional and population levels in both health and disease. Examples are: -studies of blood groups and other surface antigens- cell interactions and immune response- receptors, antibodies, complement components and cytokines- polymorphism- evolution of the organisation, control and function of immune system components- anthropology and disease associations- the genetics of immune-related disease: allergy, autoimmunity, immunodeficiency and other immune pathologies- All papers are seen by at least two independent referees and only papers of the highest quality are accepted.