Combined Role of Inflammatory Biomarkers and Red Blood Cell Distribution Width in Predicting In-hospital Outcomes of Acute Ischemic Stroke Patients Undergoing Thrombolysis.

IF 2 4区医学 Q3 CLINICAL NEUROLOGY

Current neurovascular research Pub Date : 2023-01-01 DOI:10.2174/1567202620666230606120439

Yi Wang, Yafang Zhu, Xiaohong Wang, Chongke Zhong, Yan Qin, Yongrong Sun, Yongjun Cao, Xia Zhang, Dongqin Chen

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引用次数: 0

Abstract

Background: To investigate the combined effect of red blood cell distribution width (RDW) and inflammatory biomarkers on in-hospital outcomes of acute ischemic stroke(AIS) patients with thrombolysis.

Methods: 417 AIS patients with thrombolysis were included. The participants were divided into four groups according to the cut-off of white blood cell (WBC) or C reactive protein (CRP) and RDW: LWLR, LWHR, HWLR, and HWHR; or LCLR, LCHR, HCLR, and HCHR (L-low, Hhigh, W-WBC, C-CRP, R-RDW). Logistic regression models were used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of in-hospital pneumonia and functional outcome across the four subgroups.

Results: Patients with higher RDW and inflammatory biomarkers levels have the highest risk of in-hospital outcomes. Compared with patients in the LWLR group, the ORs (95% CIs) of those in the HWHR group were 12.16 (4.21-35.14) and 9.31 (3.19-27.17) for in-hospital pneumonia and functional outcome. The ORs (95% CIs) of those in the HCHR group were 6.93 (2.70-17.78) and 3.38 (1.10-10.39) for in-hospital pneumonia and functional outcome, compared with patients in the LCLR group. Simultaneously adding RDW and WBC or CRP to the basic model with established risk factors significantly improved risk discrimination and reclassification for pneumonia and functional outcome (all p <0.05).

Conclusions: Combined RDW and inflammatory biomarkers within 4.5 hours had a better predictive power for in-hospital outcomes of AIS patients with thrombolysis.

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炎症生物标志物和红细胞分布宽度在预测急性缺血性脑卒中溶栓患者住院预后中的联合作用

背景:探讨红细胞分布宽度(RDW)和炎症生物标志物对急性缺血性脑卒中(AIS)溶栓患者住院预后的联合影响。方法:纳入417例AIS溶栓患者。根据白细胞(WBC)或C反应蛋白(CRP)和RDW的临界值将参与者分为四组:LWLR、LWHR、HWLR和HWHR;或LCLR、LCHR、HCLR、HCHR (L-low、high、W-WBC、C-CRP、R-RDW)。采用Logistic回归模型计算4个亚组住院肺炎和功能结局的比值比(ORs)和95%置信区间(CIs)。结果:RDW和炎症生物标志物水平较高的患者住院预后风险最高。与LWLR组相比，HWHR组住院肺炎和功能结局的or (95% ci)分别为12.16(4.21-35.14)和9.31(3.19-27.17)。与LCLR组相比，HCHR组住院肺炎和功能结局的or (95% ci)分别为6.93(2.70-17.78)和3.38(1.10-10.39)。在已确定危险因素的基础模型中同时加入RDW和WBC或CRP，可显著提高肺炎和功能结局的风险区分和重新分类(均p)。结论:4.5小时内联合RDW和炎症生物标志物对AIS溶栓患者的院内结局具有更好的预测能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current neurovascular research 医学-临床神经学

CiteScore

3.80

自引率

9.50%

发文量

审稿时长

3 months

期刊介绍： Current Neurovascular Research provides a cross platform for the publication of scientifically rigorous research that addresses disease mechanisms of both neuronal and vascular origins in neuroscience. The journal serves as an international forum publishing novel and original work as well as timely neuroscience research articles, full-length/mini reviews in the disciplines of cell developmental disorders, plasticity, and degeneration that bridges the gap between basic science research and clinical discovery. Current Neurovascular Research emphasizes the elucidation of disease mechanisms, both cellular and molecular, which can impact the development of unique therapeutic strategies for neuronal and vascular disorders.