Long Non-Coding RNA Signatures in Lymphopoiesis and Lymphoid Malignancies.

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-Coding RNA Pub Date : 2023-08-01 DOI:10.3390/ncrna9040044

Hamed Baghdadi, Reza Heidari, Mahdi Zavvar, Nazanin Ahmadi, Mehdi Shakouri Khomartash, Mahmoud Vahidi, Mojgan Mohammadimehr, Davood Bashash, Mahdi Ghorbani

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Abstract

Lymphoid cells play a critical role in the immune system, which includes three subgroups of T, B, and NK cells. Recognition of the complexity of the human genetics transcriptome in lymphopoiesis has revolutionized our understanding of the regulatory potential of RNA in normal lymphopoiesis and lymphoid malignancies. Long non-coding RNAs (lncRNAs) are a class of RNA molecules greater than 200 nucleotides in length. LncRNAs have recently attracted much attention due to their critical roles in various biological processes, including gene regulation, chromatin organization, and cell cycle control. LncRNAs can also be used for cell differentiation and cell fate, as their expression patterns are often specific to particular cell types or developmental stages. Additionally, lncRNAs have been implicated in lymphoid differentiation, such as regulating T-cell and B-cell development, and their expression has been linked to immune-associated diseases such as leukemia and lymphoma. In addition, lncRNAs have been investigated as potential biomarkers for diagnosis, prognosis, and therapeutic response to disease management. In this review, we provide an overview of the current knowledge about the regulatory role of lncRNAs in physiopathology processes during normal lymphopoiesis and lymphoid leukemia.

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淋巴细胞生成和淋巴恶性肿瘤中的长非编码 RNA 特征

淋巴细胞在免疫系统中发挥着关键作用，它包括 T、B 和 NK 细胞三个亚群。人类基因转录组在淋巴造血过程中的复杂性已被认识，这彻底改变了我们对 RNA 在正常淋巴造血和淋巴恶性肿瘤中的调控潜力的理解。长非编码 RNA（lncRNA）是一类长度超过 200 个核苷酸的 RNA 分子。LncRNA 在基因调控、染色质组织和细胞周期控制等各种生物过程中发挥着关键作用，因此近来备受关注。LncRNA 还可用于研究细胞分化和细胞命运，因为它们的表达模式往往是特定细胞类型或发育阶段所特有的。此外，lncRNA 还与淋巴分化有关，如调节 T 细胞和 B 细胞的发育，其表达与免疫相关疾病（如白血病和淋巴瘤）有关。此外，lncRNAs 还被研究作为诊断、预后和疾病治疗反应的潜在生物标志物。在这篇综述中，我们将概述目前关于 lncRNA 在正常淋巴细胞生成和淋巴白血病的生理病理过程中的调控作用的知识。

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来源期刊

Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

6.70

自引率

4.70%

发文量

审稿时长

10 weeks

期刊介绍： Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.