Sonographic changes in the thyroid gland after sclerotherapy with doxycycline can be mistaken for thyroid cancer.

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM
Steven Raeymaeckers, Maurizio Tosi, Bastiaan Sol, Johan De Mey
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Abstract

Background: The literature considers sclerotherapy to be a safe and effective treatment for benign thyroid cysts. No subsequent diagnostic problems have been reported as a complication. We report the occurrence of focal inflammation after said therapy, mimicking a thyroid malignancy.

Case presentation: We report a case of a young male with a solitary strongly suspicious lesion in the thyroid. The patient had undergone prior sclerotherapy of a thyroid cyst with Doxycycline. The lesion appeared to be a focal area of inflammation and thus iatrogenic in nature. Systemic use of doxycycline is known to sometimes cause a non-immune chemical thyroiditis, dubbed as black thyroid due to the intense black discoloration of the thyroid. It might be that the instillation of doxycycline was responsible for a similar, more localized area of thyroiditis.

Conclusions: For the work-up of a solitary suspicious thyroid lesion, the medical history of the patient should always be considered. In case of prior ipsilateral sclerotherapy, a reactive inflammatory response may mimic thyroid malignancy. A fine needle aspiration should be performed to exclude thyroid cancer. Treatment is not necessary; the process appears to be self-limiting as evidenced in the follow-up of this case.

强力霉素硬化治疗后甲状腺超声变化可被误认为甲状腺癌。
背景:文献认为硬化疗法是一种安全有效的治疗良性甲状腺囊肿的方法。没有后续诊断问题被报道为并发症。我们报告局灶性炎症的发生后,上述治疗,模仿甲状腺恶性肿瘤。病例介绍:我们报告一例年轻男性与一个孤立的强烈可疑病变在甲状腺。患者曾接受多西环素甲状腺囊肿硬化治疗。病变似乎是炎症的焦点区域,因此在本质上是医源性的。众所周知,系统使用强力霉素有时会引起非免疫性化学甲状腺炎,由于甲状腺呈强烈的黑色变色,被称为黑色甲状腺。这可能是多西环素的灌注负责一个类似的,更局部的区域甲状腺炎。结论:对单发可疑甲状腺病变的检查,应充分考虑患者的病史。在先前同侧硬化治疗的情况下,反应性炎症反应可能模仿甲状腺恶性肿瘤。应进行细针抽吸以排除甲状腺癌。治疗是不必要的;这一过程似乎是自我限制的,这在本病例的后续行动中得到了证明。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Thyroid Research
Thyroid Research Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
3.10
自引率
4.50%
发文量
21
审稿时长
8 weeks
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