Trehalose and its Diverse Biological Potential.

IF 1.9 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current protein & peptide science Pub Date : 2023-01-01 DOI:10.2174/1389203724666230606154719

Eva Sharma, P S Shruti, Shagun Singh, Tashvinder Singh, Prabhsimran Kaur, Bhavana Jodha, Yashi Srivastava, Anjana Munshi, Sandeep Singh

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引用次数: 2

Abstract

Trehalose, a disaccharide molecule of natural origin, is known for its diverse biological applications, like in drug development, research application, natural scaffold, stem cell preservation, food, and various other industries. This review has discussed one such diverse molecule 'trehalose aka mycose', and its diverse biological applications with respect to therapeutics. Due to its inertness and higher stability at variable temperatures, it has been developed as a preservative to store stem cells, and later, it has been found to have anticancer properties. Trehalose has recently been associated with modulating cancer cell metabolism, diverse molecular processes, neuroprotective effect, and so on. This article describes the development of trehalose as a cryoprotectant and protein stabilizer as well as a dietary component and therapeutic agent against various diseases. The article discusses its role in diseases via modulation of autophagy, various anticancer pathways, metabolism, inflammation, aging and oxidative stress, cancer metastasis and apoptosis, thus highlighting its diverse biological potential.

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海藻糖及其多样性生物潜力。

海藻糖是一种天然来源的双糖分子，因其广泛的生物应用而闻名，如药物开发、研究应用、天然支架、干细胞保存、食品和其他各种行业。这篇综述讨论了一种这样的多样化分子“海藻糖又名真菌”，以及它在治疗方面的多种生物学应用。由于它的惰性和在不同温度下更高的稳定性，它被开发为储存干细胞的防腐剂，后来，它被发现具有抗癌特性。海藻糖近年来与调节癌细胞代谢、多种分子过程、神经保护作用等有关。本文介绍海藻糖作为冷冻保护剂和蛋白质稳定剂的发展，以及作为膳食成分和治疗各种疾病的药物。本文讨论了其在自噬、各种抗癌途径、代谢、炎症、衰老和氧化应激、癌症转移和细胞凋亡等疾病中的作用，从而突出了其多种生物学潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current protein & peptide science 生物-生化与分子生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.