Temporal Pattern of Cortical Hypoxia in Multiple Sclerosis and Its Significance on Neuropsychological and Clinical Measures of Disability

IF 8.1 1区医学 Q1 CLINICAL NEUROLOGY

Annals of Neurology Pub Date : 2023-08-22 DOI:10.1002/ana.26769

Damilola D. Adingupu PhD, Taelor Evans MSc, Ateyeh Soroush BSc, Ayden Hansen BSc, Scott Jarvis MD, PhD, FRCPC, Lenora Brown PhD, ABPP, Jeff F. Dunn PhD

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引用次数: 0

Abstract

Objective

Multiple sclerosis (MS) is a degenerative disease of the central nervous system (CNS) characterized by inflammation, demyelination, and axonal damage. It has been hypothesized that hypoxia plays a role in the pathogenesis of MS. This study was undertaken to investigate the reproducibility of non-invasively measured cortical microvascular hemoglobin oxygenation (S_tO₂) using frequency domain near-infrared spectroscopy (fdNIRS), investigate its temporal pattern of hypoxia in people with MS (pwMS), and its relationship with neurocognitive function and mood.

Methods

We investigated the reproducibility of fdNIRS measurements. We measured cortical hypoxia in pwMS, and the relationships between S_tO₂, neurocognitive function, fatigue, and measures of physical disability. Furthermore, we cataloged the temporal pattern of S_tO₂ measured at 1-week intervals for 4 weeks, and at 8 weeks and ~1 year.

Results

We show that fdNIRS parameters were highly reproducible in 7 healthy control participants measured over 6 days (p > 0.05). There was low variability between and within subjects. In line with our previous findings, we show that 33% of pwMS (n = 88) have cortical microvascular hypoxia. Over 8 weeks and at ~1 year, S_tO₂ values for normoxic and hypoxic groups did not change significantly. There was no significant association between cognitive function and S_tO₂. This conclusion should be revisited as only a small proportion of the relapsing-remitting MS group (21%) was cognitively impaired.

Interpretation

The fdNIRS parameters have high reproducibility and repeatability, and we have demonstrated that hypoxia in MS is a chronic condition, lasting at least a year. The results show a weak relationship between cognitive functioning and oxygenation, indicating future study is required. ANN NEUROL 2023;94:1067–1079

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查看原文本刊更多论文

多发性硬化症皮质缺氧的时间模式及其在残疾神经心理学和临床测量中的意义。

目的：多发性硬化症（MS）是一种以炎症、脱髓鞘和轴突损伤为特征的中枢神经系统退行性疾病。假设缺氧在MS的发病机制中起作用。本研究采用频域近红外光谱（fdNIRS）研究了非侵入性测量的皮层微血管血红蛋白氧合（St O2）的再现性，以及它与神经认知功能和情绪的关系。方法：我们研究了fdNIRS测量的再现性。我们测量了pwMS中的皮层缺氧，以及St O2、神经认知功能、疲劳和身体残疾测量之间的关系。此外，我们对4周内以1周为间隔测量的St O2的时间模式进行了编目周，8点周和~1 年结果：我们发现fdNIRS参数在7名健康对照参与者中具有高度可重复性，测量时间超过6 天（p > 0.05）。受试者之间和受试者内部的变异性较低。与我们之前的研究结果一致，我们发现33%的pwMS（n = 88）具有皮质微血管缺氧。超过8 周，在~1 年，常氧组和低氧组的St O2值没有显著变化。认知功能与St O2之间没有显著的相关性。这一结论应该重新考虑，因为复发-缓解型多发性硬化症组中只有一小部分（21%）存在认知障碍。解释：fdNIRS参数具有高再现性和可重复性，我们已经证明MS缺氧是一种慢性疾病，至少持续一年。研究结果表明，认知功能和氧合之间的关系较弱，这表明需要进一步的研究。ANN NEUROL 2023。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Neurology 医学-临床神经学

CiteScore

18.00

自引率

1.80%

发文量

270

审稿时长

3-8 weeks

期刊介绍： Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.