Extracellular Vesicles from Urine-Derived Stem Cell for Tissue Engineering and Regenerative Medicine.

IF 5.1 2区 医学 Q2 CELL & TISSUE ENGINEERING
Tissue Engineering. Part B, Reviews Pub Date : 2024-04-01 Epub Date: 2023-09-22 DOI:10.1089/ten.TEB.2023.0100
Yi-Jun Dong, Juan-Juan Hu, Yu-Ting Song, Ya-Ya Gao, Mei-Jun Zheng, Chen-Yu Zou, Ming Xiong, Jesse Li-Ling, Hui Yang, Hui-Qi Xie
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引用次数: 0

Abstract

The potential of urine-derived stem cells (USCs) for tissue engineering and regenerative medicine has attracted much attention during the last few decades. However, it has been suggested that the effects of the USCs may be endowed by their paracrine extracellular vesicles (EVs) rather than their differentiation. Compared with the USCs, the USC-EVs can cross the barriers more easily and safely, and their inclusions may mediate intercellular communication and promote the tissue repair. This article has summarized the current knowledge and applications about the USC-EVs in tissue engineering and regenerative medicine, and discussed the prospects and challenges for using them as an alternative to cell therapy. Impact statement Urine-derived stem cells (USCs) represent a newly discovered type of stem cells, and studies have proved that the beneficial effects of the USCs may be manifested through their paracrine extracellular vesicles (EVs) rather than through their own differentiation, which opens up new avenues for tissue engineering and regenerative medicine strategies. Therefore, this review aims to summarize the latest research progress and potential clinical applications of the USC-EVs, highlighting the promising potential of the USC-EVs as a therapeutic option in kidney regeneration, genital regeneration, nerve regeneration, bone and cartilage regeneration, and wound healing.

用于组织工程和再生医学的尿来源干细胞的细胞外小泡。
在过去的几十年里,尿液来源的干细胞在组织工程和再生医学中的潜力引起了人们的广泛关注。然而,有人认为,USCs的作用可能是由其旁分泌细胞外小泡(EV)赋予的,而不是由其分化赋予的。与USCs相比,USC-EVs可以更容易、更安全地跨越屏障,其内含物可以介导细胞间通讯,促进组织修复。本文总结了USC EV在组织工程和再生医学中的最新知识和应用,并讨论了将其作为细胞治疗的替代品的前景和挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tissue Engineering. Part B, Reviews
Tissue Engineering. Part B, Reviews Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
12.80
自引率
1.60%
发文量
150
期刊介绍: Tissue Engineering Reviews (Part B) meets the urgent need for high-quality review articles by presenting critical literature overviews and systematic summaries of research within the field to assess the current standing and future directions within relevant areas and technologies. Part B publishes bi-monthly.
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