Silvana Condemi , Michel Panuel , Kathia Chaumoitre , Maria Giovanna Belcastro , Annalisa Pietrobelli , Jean-Luc Voisin
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引用次数: 0
Abstract
Objective
To discuss a Neandertal pathological adult first pollical proximal phalanx (I2-104) from the Baume de Moula-Guercy (Ardèche, France) and evaluate the possible causes of this pathology.
Methods
Macroscopic analyses of external features, as well as CT imaging, were used in the analysis
Results
The presence of asymmetric eburnation on the distal epiphysis associated with an osteophyte on the palmar surface, as well as the absence of periosteal bone reaction visible on CT images, is consistent with osteoarthritis.
Conclusion
Osteoarthritis (OA) can have different origins and the cause is difficult to identify. The pathology of the Moula-Guercy I2-104 phalanx may be due to a genetic predisposition for OA known in Neandertals and associated with short limb bones. The OA could have been aggravated by the age of this individual and by an inflammatory reaction caused by repeated movements and intense vibrations provoked by high-frequency knapping or by other use of the hands
Significance
The I2-104 phalanx is the first Neandertal pollical phalanx known to display OA, although joints of this bone are frequently affected by this pathology in modern humans. Thus, greater insight into the presence and consequences of Neandertal behaviors is offered
Limitation
It is impossible to give a definitive conclusion on the cause(s) of the OA in this case.
Suggestions for further research
More data is needed concerning OA within Neandertals and its relationship with behavior and genetics.
目的探讨来自法国ard区Baume de Moula-Guercy的一具尼安德特人成年病理性第一政治近端指骨(I2-104)，并探讨其可能的病因。结果远端骨骺不对称灼烧伴掌面骨赘，CT上未见骨膜反应，与骨关节炎相一致。结论骨关节炎(OA)可有多种发病原因，其病因难以确定。莫拉-格西I2-104指骨的病理可能是由于在尼安德特人中已知的OA遗传易感性，并与短肢骨有关。骨性关节炎可能因个体的年龄和由高频敲击或其他手的使用引起的反复运动和强烈振动引起的炎症反应而加剧。意义I2-104指骨是已知的第一个显示骨性关节炎的尼安德特人政治指骨，尽管该骨的关节经常受到这种病理的影响。因此，对尼安德特人行为的存在和后果提供了更深入的了解。局限性:在这种情况下，不可能对OA的原因给出明确的结论。关于尼安德特人的骨关节炎及其与行为和遗传的关系，需要更多的数据。
期刊介绍：
Paleopathology is the study and application of methods and techniques for investigating diseases and related conditions from skeletal and soft tissue remains. The International Journal of Paleopathology (IJPP) will publish original and significant articles on human and animal (including hominids) disease, based upon the study of physical remains, including osseous, dental, and preserved soft tissues at a range of methodological levels, from direct observation to molecular, chemical, histological and radiographic analysis. Discussion of ways in which these methods can be applied to the reconstruction of health, disease and life histories in the past is central to the discipline, so the journal would also encourage papers covering interpretive and theoretical issues, and those that place the study of disease at the centre of a bioarchaeological or biocultural approach. Papers dealing with historical evidence relating to disease in the past (rather than history of medicine) will also be published. The journal will also accept significant studies that applied previously developed techniques to new materials, setting the research in the context of current debates on past human and animal health.
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