Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle.

IF 4.9 2区医学 Q1 PHYSIOLOGY

Exercise and Sport Sciences Reviews Pub Date : 2022-10-01 Epub Date: 2022-06-24 DOI:10.1249/JES.0000000000000301

Matthew A Romero, Petey W Mumford, Paul A Roberson, Shelby C Osburn, Kaelin C Young, John M Sedivy, Michael D Roberts

引用次数: 1

Abstract

Retrotransposons are gene segments that proliferate in the genome, and the Long INterspersed Element 1 (LINE-1 or L1) retrotransposon is active in humans. Although older mammals show enhanced skeletal muscle L1 expression, exercise generally reverses this trend. We hypothesize skeletal muscle L1 expression influences muscle physiology, and additional innovative investigations are needed to confirm this hypothesis.

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LINE-1跳跃基因在骨骼肌中的翻译意义。

反转录转座子是在基因组中增殖的基因片段，长插入元件1（LINE-1或L1）反转录转座子在人类中具有活性。尽管年龄较大的哺乳动物骨骼肌L1表达增强，但运动通常会逆转这一趋势。我们假设骨骼肌L1的表达会影响肌肉生理，需要更多的创新研究来证实这一假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Exercise and Sport Sciences Reviews 社会科学-生理学

CiteScore

10.70

自引率

1.80%

发文量

期刊介绍： Exercise and Sport Sciences Reviews made the transition from an annual hardcover series book to a quarterly journal in January 2000. The mission of this American College of Sports Medicine publication is to provide premier quarterly reviews of the most contemporary scientific, medical, and research-based topics emerging in the field of sports medicine and exercise science. The publication strives to provide the most relevant, topical information to students, professors, clinicians, scientists, and professionals for practical and research applications.