Management of Vandhyatva w.s.r. to thin endometrium through Ayurveda- A single arm open labelled pilot clinical trial.

Ayu Pub Date : 2021-10-01 Epub Date: 2023-05-17 DOI:10.4103/ayu.ayu_132_21

Jalpa Deepak Rupareliya, Shilpa Donga, Abhay Jayprakash Gandhi

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Abstract

Background: The four essential factors of conception are Ritu (optimum period for conception), Kshetra (place of conception), Ambu (nutrition), and Beeja (healthy sperm and ovum). Kshetra denotes body as general and to be very specific, especially about the female reproductive system, it is Garbhashaya or the uterine cavity and function is Garbhadhana or conception. The endometrial factor is an important subset in infertility due to poor implantation.

Aims: To evaluate the efficacy of Saubhagyanandana Ghrita Yonipichu (vaginal tampoon) and Jeevaniya Churna orally in the management of thin endometrium thickness and to evaluate its efficacy in the associate complains of menstrual abnormalities, i.e., irregularity of menstrual cycle, quantity, duration and pain.

Materials and methods: It was a single-arm open labeled pilot clinical trial, a total of 15 female patients having endometrial thickness <7 mm on transvaginal sonography findings were included in the study. Each patient (n = 15) was given Saubhagyanandana Ghrita Yonipichu (10 mL for 6 days after cessation of menses, for 1 cycle) along with Jeevaniya Churna orally 10 g along with milk twice before meals for 30 days. Assessment of the study was done on Appelbaum's uterine scoring system for the reproduction (USSR) scoring pattern.

Results: Results were analyzed by the paired' t-test for the objective parameters and Wilcoxon signed rank-sum test for the subjective parameters. A statistically highly significant difference (P < 0.001) was seen in endometrium thickness, layering, myometrial echogenicity, uterine Doppler flow, endometrial blood flow in zone 3, and total USSR score. Statistical significant difference (P < 0.05) was found in the menstrual abnormalities and a highly statistically significant difference (P < 0.001) was found in ovulation. One of the patients conceived after the treatment.

Conclusion: Saubhagyanandana Ghrita Yonipichu (vaginal tampoon) and Jeevaniya Churna orally are effective in improving the thin endometrium.

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通过阿育吠陀对Vandhyatva w.s.r.治疗子宫内膜变薄——一项单臂开放标记的试点临床试验。

背景：受孕的四个基本因素是Ritu（最佳受孕期）、Kshetra（受孕地点）、Ambu（营养）和Beeja（健康的精子和卵子）。Kshetra表示身体是一般的，非常具体，特别是关于女性生殖系统，它是Garbhashaya或子宫腔，功能是Garbhadhana或受孕。子宫内膜因素是由于植入不良而导致不孕的一个重要亚群。目的：评价Saubhagyanandana Ghrita Yonipichu（阴道坦蓬）和Jeevanya Churna口服治疗子宫内膜厚度薄的疗效，并评价其在月经异常（即月经周期、月经量、月经持续时间和疼痛不规律）的副主诉中的疗效。材料和方法：这是一项单臂开放标记的试点临床试验，共有15名子宫内膜厚度n=15的女性患者，在月经停止后6天内口服Saubhagyanandana Ghrita Yonipichu（10mL，1个周期）和Jeevanya Churna，每次10g，并在餐前两次加牛奶，持续30天。本研究评估了Appelbaum的生殖评分系统（苏联）评分模式。结果：对客观参数进行配对t检验，对主观参数进行Wilcoxon符号秩和检验。子宫内膜厚度、分层、子宫肌层回声、子宫多普勒血流、3区子宫内膜血流和总苏联评分存在统计学上的高度显著差异（P<0.001）。月经异常有统计学意义（P<0.05），排卵有高度统计学意义（P<0.001）。其中一名患者在治疗后受孕。结论：Saubhagyanandana Ghrita Yonipichu（阴道坦蓬）和Jeevanya Churna口服对改善子宫内膜薄有明显作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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