Relationships Between Inflammatory Parameters Derived From Complete Blood Count and Quantitative Flow Ratio in Patients With Stable Coronary Artery Disease.

IF 2.6 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Angiology Pub Date : 2025-01-01 Epub Date: 2023-08-25 DOI:10.1177/00033197231197804

Yanqing Xie, Han Cen, Li Wang, Keai Cheng, Li Huang, Haoxuan Lu, Lili Ji, Yudan Chen, Zhong Zhou, Zhuo Yang, Sheng Jing, Haibo Zhu, Kan Chen, Si Chen, Wenming He

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Abstract

To investigate the relationships between inflammatory parameters, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII), and quantitative flow ratio (QFR) in stable coronary artery disease (CAD) patients (n = 450) enrolled in this cross-sectional study. Logistic regression was performed to evaluate the associations of NLR, PLR, MLR, and SII evaluated as continuous and binary variables with QFR ≤0.80. When treated as continuous variables, lnNLR was associated with QFR ≤0.80 with borderline significance in univariable (odds ratio (OR) = 1.60, p = .05) and multivariable analysis (OR = 1.72, p = .05), while lnMLR was associated with QFR ≤0.80 significantly in univariable analysis (OR = 1.87, p = .03) and with borderline significance in multivariable analysis (OR = 1.91, p = .05). When treated as binary variables, high levels of MLR and SII were significantly associated with QFR ≤0.80 in univariable (MLR: OR = 1.91, p = .02; SII: OR = 2.42, p = .006) and multivariable analysis (MLR: OR = 1.83, p = .04; SII: OR = 2.19, p = .02). NLR, MLR, and SII, but not PLR, were significantly associated with the severity of coronary physiology in stable CAD patients.

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稳定型冠状动脉疾病患者全血细胞计数得出的炎症参数与定量血流比率之间的关系

目的：研究参加这项横断面研究的稳定型冠状动脉疾病（CAD）患者（n = 450）的炎症参数（包括中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、单核细胞与淋巴细胞比值（MLR）和全身免疫炎症指数（SII））与定量血流比率（QFR）之间的关系。为评估作为连续变量和二元变量的 NLR、PLR、MLR 和 SII 与 QFR ≤0.80 的关系，进行了逻辑回归。当作为连续变量处理时，lnNLR 与 QFR ≤0.80 的相关性在单变量分析（比值比 (OR) = 1.60，P = .05）和多变量分析（OR = 1.72，P = .05）中具有边缘显著性，而 lnMLR 与 QFR ≤0.80 的相关性在单变量分析中显著（OR = 1.87，P = .03），在多变量分析中具有边缘显著性（OR = 1.91，P = .05）。当作为二元变量处理时，在单变量分析（MLR：OR = 1.91，p = .02；SII：OR = 2.42，p = .006）和多变量分析（MLR：OR = 1.83，p = .04；SII：OR = 2.19，p = .02）中，高水平的 MLR 和 SII 与 QFR ≤0.80 显著相关。NLR、MLR和SII与稳定型CAD患者冠状动脉生理状况的严重程度显著相关，但与PLR无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Angiology 医学-外周血管病

CiteScore

5.50

自引率

14.30%

发文量

180

审稿时长

6-12 weeks

期刊介绍： A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days