Effect of nifedipine with and without sildenafil citrate for the management of preterm labor in pregnant women: A randomized clinical trial.

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY

International Journal of Reproductive Biomedicine Pub Date : 2023-05-01 DOI:10.18502/ijrm.v21i5.13471

Shahla Nasrolahei, Seyedeh Arezoo Hoseini, Seyedeh Azadeh Hosseini, Seyedeh Narjes Khatoon Hosseini, Seyedeh Sahar Hosseini, Parsa Moradian Lotfi

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引用次数: 1

Abstract

Background: Preterm labor is one of the main causes of neonatal mortality and its treatment is still challenging.

Objective: The study aimed to compare the effectiveness of nifedipine (Nif) with and without sildenafil citrate (SC) for the treatment of preterm labor in pregnant women.

Materials and methods: In this clinical trial study, 126 pregnant women referred to the Fatemieh hospital, Hamadan, Iran with a complaint of preterm labor were evaluated. Participants were randomly divided into 2 groups of Nif 20 mg orally (single dose), then 10 mg every 6-hr, and at the same time vaginal SC 25 mg every 8 hr (Nif + SC) or Nif alone. Treatment was continued for 48-72 hr if uterine contractions did not resolve in both groups. Delivery rates at the time of hospitalization and neonatal outcome were compared between the 2 groups.

Results: No statistically significant difference was observed between the 2 study groups in terms of mean age, gestational age, body mass index, and parity. 76.2% of Nif + SC participants in the first 72 hr of hospitalization and 57.2% of Nif participants remained without delivery (p = 0.02). The neonatal hospitalization rate of the Nif + SC group in the neonatal intensive care unit was 25.4% and in the Nif group was 42.9% (p = 0.03).

Conclusion: Nif with SC is superior to Nif alone in women at risk of preterm labor due to increasing gestational age and better neonatal outcomes.

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硝苯地平联合和不联合枸橼酸西地那非治疗孕妇早产的效果:一项随机临床试验。

背景:早产是新生儿死亡的主要原因之一，其治疗仍然具有挑战性。目的:比较硝苯地平(Nif)与枸橼酸西地那非(SC)合用和不合用硝苯地平治疗孕妇早产的效果。材料和方法:在这项临床试验研究中，对126名到伊朗哈马丹Fatemieh医院就诊的早产孕妇进行了评估。参与者随机分为两组，口服Nif 20 mg(单次剂量)，然后每6小时10 mg，同时阴道SC每8小时25 mg (Nif + SC)或单独使用Nif。如果两组的子宫收缩未消除，则继续治疗48-72小时。比较两组患者住院时的分娩率和新生儿结局。结果:两组患者的平均年龄、胎龄、体重指数、胎次差异均无统计学意义。76.2%的Nif + SC参与者在住院后72小时内没有分娩，57.2%的Nif参与者没有分娩(p = 0.02)。新生儿重症监护病房Nif + SC组新生儿住院率为25.4%，Nif组为42.9% (p = 0.03)。结论:由于胎龄增加和新生儿结局更好，在有早产风险的妇女中，Nif联合SC优于单独使用Nif。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Reproductive Biomedicine OBSTETRICS & GYNECOLOGY-

CiteScore

2.40

自引率

7.70%

发文量

审稿时长

16 weeks

期刊介绍： The International Journal of Reproductive BioMedicine (IJRM), formerly published as "Iranian Journal of Reproductive Medicine (ISSN: 1680-6433)", is an international monthly scientific journal for who treat and investigate problems of infertility and human reproductive disorders. This journal accepts Original Papers, Review Articles, Short Communications, Case Reports, Photo Clinics, and Letters to the Editor in the fields of fertility and infertility, ethical and social issues of assisted reproductive technologies, cellular and molecular biology of reproduction including the development of gametes and early embryos, assisted reproductive technologies in model system and in a clinical environment, reproductive endocrinology, andrology, epidemiology, pathology, genetics, oncology, surgery, psychology, and physiology. Emerging topics including cloning and stem cells are encouraged.