Is fibromyalgia an autoimmune disorder?

IF 9.2 1区医学 Q1 IMMUNOLOGY

Autoimmunity reviews Pub Date : 2024-01-01 DOI:10.1016/j.autrev.2023.103424

Daniel Clauw , Piercarlo Sarzi-Puttini , Greta Pellegrino , Yehuda Shoenfeld

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引用次数: 0

Abstract

Fibromyalgia (FM) is a multifactorial syndrome which includes not only widespread pain and stiffness, now recognized as major symptoms, but also numerous other somatic, emotional, and neuropsychic manifestation. The lack of specific validated biological and instrumental biomarkers has made FM a condition of unexplained medical significance, and its pathophysiology remains controversial and subject to debate. The current hypothesis regarding the pathogenesis of FM proposes that its development is influenced by various mechanism, including genetic predisposition, stressful life events, inflammatory processes, and cognitive-emotional factors. However, despite the extensive research conducted to date, the available data do not provide a clear understanding of the pathogenesis of FM.

In this article, we report the opposing viewpoints of two leading experts who debate the question of whether FM is an autoimmune disease, based on scientific data regarding this condition. Both perspectives are discussed and the latest evidence on the pathophysiology of FM is reported to provide a comprehensive understanding of this complex syndrome.

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纤维肌痛是一种自身免疫性疾病吗？

纤维肌痛（FM）是一种多因素综合征，不仅包括广泛的疼痛和僵硬，现在被认为是主要症状，还包括许多其他身体、情绪和神经精神表现。由于缺乏特定的经验证的生物和仪器生物标志物，FM成为一种具有无法解释的医学意义的疾病，其病理生理学仍然存在争议和争论。目前关于FM发病机制的假说认为，FM的发展受到各种机制的影响，包括遗传易感性、压力性生活事件、炎症过程和认知情绪因素。然而，尽管迄今为止进行了广泛的研究，但现有数据并不能清楚地了解FM的发病机制。在这篇文章中，我们报道了两位主要专家的对立观点，他们根据有关FM是否是一种自身免疫性疾病的科学数据，就FM是否是这种疾病的问题进行了辩论。对这两种观点进行了讨论，并报道了FM病理生理学的最新证据，以全面了解这种复杂的综合征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autoimmunity reviews 医学-免疫学

CiteScore

24.70

自引率

4.40%

发文量

164

审稿时长

21 days

期刊介绍： Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.