Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability.

IF 4.9 2区医学 Q1 PHYSIOLOGY

Exercise and Sport Sciences Reviews Pub Date : 2021-10-01 DOI:10.1249/JES.0000000000000265

Michael D Tarpey, Adam J Amorese, Elizabeth R LaFave, Everett C Minchew, Kelsey H Fisher-Wellman, Joseph M McClung, Eli G Hvastkovs, Espen E Spangenburg

引用次数: 0

Abstract

Breast Cancer gene 1 (BRCA1) is a large, multifunctional protein that regulates a variety of mechanisms in multiple different tissues. Our work established that Brca1 is expressed in skeletal muscle and localizes to the mitochondria and nucleus. Here, we propose BRCA1 expression is critical for the maintenance of force production and mitochondrial respiration in skeletal muscle.

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骨骼肌功能依赖BRCA1维持基因组稳定性。

乳腺癌基因1 (BRCA1)是一个大的、多功能的蛋白，在多个不同的组织中调节多种机制。我们的工作证实Brca1在骨骼肌中表达，并定位于线粒体和细胞核。在这里，我们提出BRCA1表达对于维持骨骼肌的力量产生和线粒体呼吸至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Exercise and Sport Sciences Reviews 社会科学-生理学

CiteScore

10.70

自引率

1.80%

发文量

期刊介绍： Exercise and Sport Sciences Reviews made the transition from an annual hardcover series book to a quarterly journal in January 2000. The mission of this American College of Sports Medicine publication is to provide premier quarterly reviews of the most contemporary scientific, medical, and research-based topics emerging in the field of sports medicine and exercise science. The publication strives to provide the most relevant, topical information to students, professors, clinicians, scientists, and professionals for practical and research applications.