Associations of attention-deficit/hyperactivity disorder with inflammatory diseases. Results from the nationwide German Health Interview and Examination Survey for Children and Adolescents (KiGGS).

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-08-17 DOI:10.1007/s40211-023-00479-8

Lena Boemanns, Julia Staab, Thomas Meyer

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引用次数: 0

Abstract

Background: Despite conflicting data, some studies have suggested a pathophysiological relationship between inflammation and attention-deficit/hyperactivity disorder (ADHD).

Methods: Using data from the nationwide and representative German Health Interview and Examination Survey for Children and Adolescents (KiGGS; n = 6922 study participants aged 11-17 years), this post hoc analysis assessed the associations between ADHD and three common inflammatory diseases.

Results: Results showed univariate associations between ADHD and lifetime inflammatory diseases including atopic dermatitis (p = 0.002), otitis media (p = 0.001), and herpes simplex infection (p = 0.032). In logistic regression models adjusted for clinically relevant confounders, we found that ADHD remained a significant predictor of all three inflammatory diseases (atopic dermatitis, Exp(β) = 1.672, 95% confidence interval [CI] 1.239-2.257, p = 0.001; otitis media, Exp(β) = 1.571, 95% CI 1.209-2.040, p = 0.001; herpes simplex, Exp(β) = 1.483, 95% CI 1.137-1.933, p = 0.004).

Conclusion: Our findings demonstrate a positive link between ADHD and peripheral inflammatory diseases, including atopic dermatitis, otitis media, and herpes simplex infection. Further studies are needed to understand the exact pathophysiological mechanisms underlying these associations.

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注意缺陷/多动障碍与炎症性疾病的关系德国全国儿童和青少年健康访谈和检查调查(KiGGS)的结果。

背景:尽管数据相互矛盾，但一些研究表明炎症与注意缺陷/多动障碍(ADHD)之间存在病理生理关系。方法:采用德国儿童和青少年健康访谈和检查调查(KiGGS;n = 6922名11-17岁的研究参与者)，这项事后分析评估了ADHD与三种常见炎症疾病之间的关系。结果:结果显示ADHD与终生炎症性疾病之间存在单变量关联，包括特应性皮炎(p = 0.002)、中耳炎(p = 0.001)和单纯疱疹感染(p = 0.032)。在校正临床相关混杂因素的logistic回归模型中，我们发现ADHD仍然是所有三种炎症性疾病(特应性皮炎)的显著预测因子，Exp(β) = 1.672,95%可信区间[CI] 1.239-2.257, p = 0.001;中耳炎,Exp(β) = 1.571,95% CI 1.209 - -2.040, p = 0.001;单纯疱疹,Exp(β) = 1.483,95% CI 1.137 - -1.933, p = 0.004)。结论:我们的研究结果表明ADHD与周围炎性疾病，包括特应性皮炎、中耳炎和单纯疱疹感染之间存在正相关。需要进一步的研究来了解这些关联背后的确切病理生理机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.