NIR light-facilitated bone tissue engineering.

IF 6.9 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2024-01-01 Epub Date: 2023-08-26 DOI:10.1002/wnan.1925

Qian Feng, Xiaojun Zhou, Chuanglong He

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Abstract

In the last decades, near-infrared (NIR) light has attracted considerable attention due to its unique properties and numerous potential applications in bioimaging and disease treatment. Bone tissue engineering for bone regeneration with the help of biomaterials is currently an effective means of treating bone defects. As a controlled light source with deeper tissue penetration, NIR light can provide real-time feedback of key information on bone regeneration in vivo utilizing fluorescence imaging and be used for bone disease treatment. This review provides a comprehensive overview of NIR light-facilitated bone tissue engineering, from the introduction of NIR probes as well as NIR light-responsive materials, and the visualization of bone regeneration to the treatment of bone-related diseases. Furthermore, the existing challenges and future development directions of NIR light-based bone tissue engineering are also discussed. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement.

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近红外光促进骨组织工程。

在过去的几十年里，近红外光由于其独特的特性和在生物成像和疾病治疗中的许多潜在应用而引起了人们的极大关注。利用生物材料进行骨组织工程骨再生是目前治疗骨缺损的有效手段。作为一种具有更深组织穿透力的受控光源，近红外光可以利用荧光成像提供体内骨再生关键信息的实时反馈，并可用于骨病治疗。这篇综述对近红外光促进的骨组织工程进行了全面的综述，从近红外探针和近红外光响应材料的引入，到骨再生的可视化，再到骨相关疾病的治疗。此外，还讨论了基于近红外光的骨组织工程存在的挑战和未来的发展方向。本文分类如下：诊断工具>体内纳米诊断和成像植入材料和外科技术>组织修复和置换中的纳米技术。

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来源期刊

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology NANOSCIENCE & NANOTECHNOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

16.60

自引率

2.30%

发文量

期刊介绍： Nanotechnology stands as one of the pivotal scientific domains of the twenty-first century, recognized universally for its transformative potential. Within the biomedical realm, nanotechnology finds crucial applications in nanobiotechnology and nanomedicine, highlighted as one of seven emerging research areas under the NIH Roadmap for Medical Research. The advancement of this field hinges upon collaborative efforts across diverse disciplines, including clinicians, biomedical engineers, materials scientists, applied physicists, and toxicologists. Recognizing the imperative for a high-caliber interdisciplinary review platform, WIREs Nanomedicine and Nanobiotechnology emerges to fulfill this critical need. Our topical coverage spans a wide spectrum, encompassing areas such as toxicology and regulatory issues, implantable materials and surgical technologies, diagnostic tools, nanotechnology approaches to biology, therapeutic approaches and drug discovery, and biology-inspired nanomaterials. Join us in exploring the frontiers of nanotechnology and its profound impact on biomedical research and healthcare.