Antifungal activity of novel azetidine tethered chitosan synthesized via multicomponent reaction approach

IF 2.2 4区医学 Q3 MYCOLOGY

Journal de mycologie medicale Pub Date : 2023-08-01 DOI:10.1016/j.mycmed.2023.101409

P. Shukla , D. Deswal , A.K. Narula

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Abstract

The increasing incidences of fungal infections among Covid-19 infected patients is a global public concern and urgently demands novel antifungals. Biopolymers like chitosan hold unique structural properties and thus can be utilized in the synthesis of biologically important scaffolds. To address the current scenario, the author's synthesized novel chitosan-azetidine derivative by adopting one-pot multicomponent reaction approach. The influence of chemical modification on the structural characteristics was investigated by means of spectroscopic techniques viz. FT-IR and ¹HNMR and elemental analysis. Additionally, the authors investigated the antifungal potential of chitosan-azetidine derivative against Aspergillus fumigatus 3007 and the results indicated higher antifungal effect with an antifungal inhibitory index of 26.19%. The SEM and confocal microscopy images also reflected a significant inhibitory effect on the morphology of fungal mycelia, thus reflecting the potential of synthesized chitosan-azetidine derivativeas a potential antifungal agent.

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多组分法合成新型氮杂啶系链壳聚糖的抗真菌活性

新冠肺炎感染患者中真菌感染的发病率不断上升，这是全球公众关注的问题，迫切需要新型抗真菌药物。壳聚糖等生物聚合物具有独特的结构特性，因此可用于合成具有重要生物学意义的支架。为了解决目前的情况，作者采用一锅多组分反应方法合成了新型壳聚糖氮杂环丁烷衍生物。用红外光谱、核磁共振氢谱和元素分析等方法研究了化学改性对其结构特征的影响。此外，作者还研究了壳聚糖-氮杂环丁烷衍生物对烟曲霉3007的抗真菌潜力，结果表明其具有较高的抗真菌效果，抗真菌抑制指数为26.19%。SEM和共聚焦显微镜图像也反映了对真菌菌丝体形态的显著抑制作用，从而反映了合成的壳聚糖氮杂环丁烷衍生物作为潜在抗真菌剂的潜力。

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来源期刊

Journal de mycologie medicale 医学-真菌学

CiteScore

5.10

自引率

2.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal de Mycologie Medicale / Journal of Medical Mycology (JMM) publishes in English works dealing with human and animal mycology. The subjects treated are focused in particular on clinical, diagnostic, epidemiological, immunological, medical, pathological, preventive or therapeutic aspects of mycoses. Also covered are basic aspects linked primarily with morphology (electronic and photonic microscopy), physiology, biochemistry, cellular and molecular biology, immunochemistry, genetics, taxonomy or phylogeny of pathogenic or opportunistic fungi and actinomycetes in humans or animals. Studies of natural products showing inhibitory activity against pathogenic fungi cannot be considered without chemical characterization and identification of the compounds responsible for the inhibitory activity. JMM publishes (guest) editorials, original articles, reviews (and minireviews), case reports, technical notes, letters to the editor and information. Only clinical cases with real originality (new species, new clinical present action, new geographical localization, etc.), and fully documented (identification methods, results, etc.), will be considered. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.