Cryptococcal meningitis in a non-HIV patient with solid organ transplantation

IF 2.2 4区医学 Q3 MYCOLOGY

Journal de mycologie medicale Pub Date : 2023-08-01 DOI:10.1016/j.mycmed.2023.101388

Mediha Ugur , Sinan Cetin , Emel Uzunoglu , Mustafa Saglam , Fatma Mutlu , Ayse Nedret Koc

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引用次数: 0

Abstract

Cryptococcal meningitis (CM) is often associated with human immunodeficiency virus (HIV). Recently, this microorganism has been increasingly identified in HIV-negative patients. CM cases are encountered in HIV-negative individuals, especially secondary to liver disease, solid organ transplantation (SOT), tuberculosis, lymphoproliferative diseases with T-cell-mediated immunological disorders, long-term corticosteroid use, malignancies, diabetes mellitus, and sarcoidosis. Our patient is an HIV-negative, SOT case with CM. It should be considered that CM can also occur in HIV-negative patients. As in our case, patients receiving long-term immunosuppressive therapy should be evaluated for CM, and renal functions should be closely monitored during treatment. There is a need for more case reports on the subject, especially in CM detected HIV-negative patients, due to the different treatment protocols and challenging clinical conditions compared to HIV-positive cases.

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非hiv患者实体器官移植的隐球菌性脑膜炎

隐球菌性脑膜炎（CM）通常与人类免疫缺陷病毒（HIV）有关。最近，这种微生物在HIV阴性患者中被越来越多地发现。CM病例发生在HIV阴性个体中，尤其是继发于肝病、实体器官移植（SOT）、结核病、伴有T细胞介导的免疫疾病的淋巴增生性疾病、长期使用皮质类固醇、恶性肿瘤、糖尿病和结节病。我们的患者是HIV阴性、SOT合并CM的病例。应该考虑到CM也可能发生在HIV阴性患者中。与我们的情况一样，接受长期免疫抑制治疗的患者应评估CM，并在治疗期间密切监测肾功能。与HIV阳性病例相比，由于不同的治疗方案和具有挑战性的临床条件，需要更多关于该主题的病例报告，特别是CM检测出的HIV阴性患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal de mycologie medicale 医学-真菌学

CiteScore

5.10

自引率

2.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal de Mycologie Medicale / Journal of Medical Mycology (JMM) publishes in English works dealing with human and animal mycology. The subjects treated are focused in particular on clinical, diagnostic, epidemiological, immunological, medical, pathological, preventive or therapeutic aspects of mycoses. Also covered are basic aspects linked primarily with morphology (electronic and photonic microscopy), physiology, biochemistry, cellular and molecular biology, immunochemistry, genetics, taxonomy or phylogeny of pathogenic or opportunistic fungi and actinomycetes in humans or animals. Studies of natural products showing inhibitory activity against pathogenic fungi cannot be considered without chemical characterization and identification of the compounds responsible for the inhibitory activity. JMM publishes (guest) editorials, original articles, reviews (and minireviews), case reports, technical notes, letters to the editor and information. Only clinical cases with real originality (new species, new clinical present action, new geographical localization, etc.), and fully documented (identification methods, results, etc.), will be considered. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.