Positivity of dengue, chikungunya, and Zika infections in women in Northeast Brazil post-Zika epidemic.

IF 4.9 4区 医学 Q1 PARASITOLOGY
Pathogens and Global Health Pub Date : 2023-07-01 Epub Date: 2022-10-31 DOI:10.1080/20477724.2022.2142187
Cristiane Cunha Frota, Francisco Gustavo Silveira Correia, Lucas Romão Alves Vasconcelos, Paulo Rafael Cardoso de Sousa, Marco Levi da Silva Ferreira, Susy Pereira Saraiva, Rafael Mota Ferreira, Kalil Andrade Mubarac Romcy, Ronald Feitosa Pinheiro, Roberta Taiane Germano de Oliveira, Francisco Marto Leal Pinheiro Júnior, Adriano Ferreira Martins, Carlos Sanhueza-Sanzana, Rosa Lívia Freitas de Almeida, Carl Kendall, Ivo Castelo Branco Coelho, Roberto da Justa Pires Neto, Ítalo Wesley Oliveira Aguiar, Ligia Regina Franco Sansigolo Kerr
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引用次数: 0

Abstract

ABSTRACT The state of Ceará, in the Northeast Region of Brazil, presents the simultaneous circulation of Zika (ZIKV), dengue (DENV) and chikungunya (CHIKV) viruses. In 2017 there were a high number of cases of these three arboviruses, especially CHIKV. Here, we detected the presence of arboviruses ZIKV, DENV and CHIKV and their coinfections in women in endemic regions of the city of Fortaleza, Ceará in a post-Zika epidemic year. Sociodemographic and environmental characteristics associated with arbovirus positivity were also analyzed. Women (n = 1289) between 15 and 39 years old were included. RT-qPCR was performed for virus detection and IgM antibody positivity was also analyzed. One hundred and six (8.3%) participants were positive for one or more arboviruses. Monoinfections (76; 5.9%) were distributed between 22 (1.7%) for ZIKV, 39 (3.1%) for DENV and 15 (1.2%) for CHIKV. Co-infections were detected in 30 (2.3%) of the positive participants and one case with triple infection was found. IgM positivity was found in 2.4% of ZIKV RT-qPCR, 9.6% of DENV and 16.3% of CHIKV. RT-qPCR positivity for arboviruses was associated with low socioeconomic class and presence of a water box sealing in the household. A higher positivity to the three viruses occurred in the month with the lowest wind velocity, which was also preceded by the highest peak of rain and humidity. We identified the simultaneous circulation and co-infection of ZIKV, DENV and CHIKV in Fortaleza in a post-Zika epidemic year. We also highlight the need for continuous epidemiological surveillance combined with molecular diagnostic tools.
寨卡病毒流行后巴西东北部妇女登革热、基孔肯雅病和寨卡病毒感染的阳性率。
巴西东北部地区的塞阿拉州同时存在寨卡病毒(ZIKV)、登革热病毒(DENV)和基孔肯雅病毒(CHIKV)的传播。2017年,这三种虫媒病毒的病例数量很高,尤其是CHIKV。在这里,我们在寨卡病毒流行后的一年中,在塞阿拉州福塔莱萨市流行地区的妇女中检测到了虫媒病毒ZIKV、DENV和CHIKV的存在及其合并感染。还分析了与虫媒病毒阳性相关的社会地理和环境特征。女性(n = 1289)在15和39之间 年龄包括在内。进行RT-qPCR进行病毒检测,并分析IgM抗体阳性。106名(8.3%)参与者对一种或多种虫媒病毒呈阳性。单感染(76例;5.9%)分布在ZIKV的22例(1.7%)、DENV的39例(3.1%)和CHIKV的15例(1.2%)之间。在30名阳性参与者中检测到共感染(2.3%),发现一例三重感染。ZIKV RT-qPCR阳性率为2.4%,DENV阳性率为9.6%,CHIKV阳性率为16.3%。虫媒病毒的RT-qPCR阳性与低社会经济阶层和家庭中存在水箱密封有关。这三种病毒的阳性率较高的月份出现在风速最低的月份,在此之前还出现了降雨量和湿度的最高峰值。我们在寨卡疫情后的一年中,在Fortaleza发现了ZIKV、DENV和CHIKV的同时循环和共同感染。我们还强调需要结合分子诊断工具进行持续的流行病学监测。
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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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