Cristiane Cunha Frota, Francisco Gustavo Silveira Correia, Lucas Romão Alves Vasconcelos, Paulo Rafael Cardoso de Sousa, Marco Levi da Silva Ferreira, Susy Pereira Saraiva, Rafael Mota Ferreira, Kalil Andrade Mubarac Romcy, Ronald Feitosa Pinheiro, Roberta Taiane Germano de Oliveira, Francisco Marto Leal Pinheiro Júnior, Adriano Ferreira Martins, Carlos Sanhueza-Sanzana, Rosa Lívia Freitas de Almeida, Carl Kendall, Ivo Castelo Branco Coelho, Roberto da Justa Pires Neto, Ítalo Wesley Oliveira Aguiar, Ligia Regina Franco Sansigolo Kerr
{"title":"Positivity of dengue, chikungunya, and Zika infections in women in Northeast Brazil post-Zika epidemic.","authors":"Cristiane Cunha Frota, Francisco Gustavo Silveira Correia, Lucas Romão Alves Vasconcelos, Paulo Rafael Cardoso de Sousa, Marco Levi da Silva Ferreira, Susy Pereira Saraiva, Rafael Mota Ferreira, Kalil Andrade Mubarac Romcy, Ronald Feitosa Pinheiro, Roberta Taiane Germano de Oliveira, Francisco Marto Leal Pinheiro Júnior, Adriano Ferreira Martins, Carlos Sanhueza-Sanzana, Rosa Lívia Freitas de Almeida, Carl Kendall, Ivo Castelo Branco Coelho, Roberto da Justa Pires Neto, Ítalo Wesley Oliveira Aguiar, Ligia Regina Franco Sansigolo Kerr","doi":"10.1080/20477724.2022.2142187","DOIUrl":null,"url":null,"abstract":"ABSTRACT The state of Ceará, in the Northeast Region of Brazil, presents the simultaneous circulation of Zika (ZIKV), dengue (DENV) and chikungunya (CHIKV) viruses. In 2017 there were a high number of cases of these three arboviruses, especially CHIKV. Here, we detected the presence of arboviruses ZIKV, DENV and CHIKV and their coinfections in women in endemic regions of the city of Fortaleza, Ceará in a post-Zika epidemic year. Sociodemographic and environmental characteristics associated with arbovirus positivity were also analyzed. Women (n = 1289) between 15 and 39 years old were included. RT-qPCR was performed for virus detection and IgM antibody positivity was also analyzed. One hundred and six (8.3%) participants were positive for one or more arboviruses. Monoinfections (76; 5.9%) were distributed between 22 (1.7%) for ZIKV, 39 (3.1%) for DENV and 15 (1.2%) for CHIKV. Co-infections were detected in 30 (2.3%) of the positive participants and one case with triple infection was found. IgM positivity was found in 2.4% of ZIKV RT-qPCR, 9.6% of DENV and 16.3% of CHIKV. RT-qPCR positivity for arboviruses was associated with low socioeconomic class and presence of a water box sealing in the household. A higher positivity to the three viruses occurred in the month with the lowest wind velocity, which was also preceded by the highest peak of rain and humidity. We identified the simultaneous circulation and co-infection of ZIKV, DENV and CHIKV in Fortaleza in a post-Zika epidemic year. We also highlight the need for continuous epidemiological surveillance combined with molecular diagnostic tools.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":"117 5","pages":"485-492"},"PeriodicalIF":4.9000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262776/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathogens and Global Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/20477724.2022.2142187","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/10/31 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PARASITOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
ABSTRACT The state of Ceará, in the Northeast Region of Brazil, presents the simultaneous circulation of Zika (ZIKV), dengue (DENV) and chikungunya (CHIKV) viruses. In 2017 there were a high number of cases of these three arboviruses, especially CHIKV. Here, we detected the presence of arboviruses ZIKV, DENV and CHIKV and their coinfections in women in endemic regions of the city of Fortaleza, Ceará in a post-Zika epidemic year. Sociodemographic and environmental characteristics associated with arbovirus positivity were also analyzed. Women (n = 1289) between 15 and 39 years old were included. RT-qPCR was performed for virus detection and IgM antibody positivity was also analyzed. One hundred and six (8.3%) participants were positive for one or more arboviruses. Monoinfections (76; 5.9%) were distributed between 22 (1.7%) for ZIKV, 39 (3.1%) for DENV and 15 (1.2%) for CHIKV. Co-infections were detected in 30 (2.3%) of the positive participants and one case with triple infection was found. IgM positivity was found in 2.4% of ZIKV RT-qPCR, 9.6% of DENV and 16.3% of CHIKV. RT-qPCR positivity for arboviruses was associated with low socioeconomic class and presence of a water box sealing in the household. A higher positivity to the three viruses occurred in the month with the lowest wind velocity, which was also preceded by the highest peak of rain and humidity. We identified the simultaneous circulation and co-infection of ZIKV, DENV and CHIKV in Fortaleza in a post-Zika epidemic year. We also highlight the need for continuous epidemiological surveillance combined with molecular diagnostic tools.
期刊介绍:
Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.