Global and regional estimates of cervical cancer burden associated with human immunodeficiency virus infection from 1990 to 2019

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2023-06-20 DOI:10.1002/jmv.28891

Zhengwei Wan, Jianhui Zhao, Liying Xu, Ping Sun, Ping Shuai, Kangning Li, Yixuan Zhang, Yan Chen, Qian Su, Xiaoqin Yao, Xue Li, Yuping Liu

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Abstract

Previous studies reported human immunodeficiency virus (HIV) could enhance human papillomavirus (HPV)-induced cervical cancer. Therefore, the burden of cervical cancer associated with HIV across different regions and time periods need to be assessed. We aim to investigate the global burden of cervical cancer associated with HIV infection. Age standardized rates (ASRs) of cervical cancer disability-adjusted life-years (DALYs) in females (≥15 years old) were calculated by standardization, according the age-specific DALYs numbers extracted from GBD data set 2019. Population attributable fractions was calculated by combining the published risk ratio, with the HIV prevalence (≥15 years old) from Joint United Nations Programme on HIV and AIDS (UNAIDS), and transferred to estimate the HIV-associated cervical cancer burden. Expected annual percentage changes (EAPCs) was calculated to describe the temporal trend of ASR from 1990 to 2019. Pearson correlation analysis were conducted to assess the correlation between the ASR or EAPCs and the socio-demographic index. The worldwide DALYs ASR caused by HIV-associated cervical cancer rose from 3.78 (95% confidence interval [CI]: 2.19–5.56) in 1990 to 9.50 (95% CI: 5.66–13.79) in 2019 per 100k population. In 2019, the region with the greatest burden was Eastern and Southern Africa, with the highest DALYs of 273 900 (95% CI: 149 100–476 400) and ASR of 254.44 per 100k population (95% CI: 168.86–329.28). Notably, the Eastern Europe and Central Asia regions had the highest EAPC (14.07%) of HIV-associated DALYs ASR. Women in Eastern and Southern Africa experience the greatest burden of HIV-associated cervical cancer, while the Eastern Europe and Central Asia regions had witnessed the largest increase over the last 30 years. Prioritize the promotion of HPV vaccination and cervical cancer screening for women living with HIV were crucial in these regions.

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1990年至2019年与人类免疫缺陷病毒感染相关的全球和区域宫颈癌负担估计

以前的研究报道了人类免疫缺陷病毒(HIV)可以增强人乳头瘤病毒(HPV)诱导的宫颈癌。因此，需要评估不同地区和不同时期与艾滋病毒相关的宫颈癌负担。我们的目的是调查与艾滋病毒感染相关的全球宫颈癌负担。根据从2019年GBD数据集中提取的年龄特异性DALYs数，通过标准化计算女性(≥15岁)宫颈癌伤残调整生命年(DALYs)的年龄标准化率(ASRs)。人口归因分数通过将公布的风险比与联合国艾滋病毒和艾滋病联合规划署(UNAIDS)的艾滋病毒患病率(≥15岁)相结合来计算，并转移到估计艾滋病毒相关的宫颈癌负担。计算预期年百分比变化(EAPCs)来描述1990 - 2019年ASR的时间趋势。采用Pearson相关分析评估ASR或EAPCs与社会人口指数之间的相关性。全球艾滋病毒相关宫颈癌引起的DALYs ASR从1990年的每10万人口3.78(95%置信区间[CI]: 2.19-5.56)上升到2019年的9.50 (95% CI: 5.66-13.79)。2019年，负担最重的区域是东部和南部非洲，DALYs最高，为273 900 (95% CI: 149 100-476 400)， ASR为每10万人口254.44 (95% CI: 168.86-329.28)。值得注意的是，东欧和中亚地区hiv相关DALYs ASR的EAPC最高(14.07%)。东部和南部非洲的妇女承受着与艾滋病毒相关的子宫颈癌的最大负担，而东欧和中亚区域在过去30年中出现了最大的增长。在这些地区，优先促进人乳头瘤病毒疫苗接种和对感染艾滋病毒的妇女进行宫颈癌筛查至关重要。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.