Serum leucine-rich α2-glycoprotein as a possible marker for inflammatory status in endometriosis.

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2023-08-21 eCollection Date: 2023-01-01 DOI:10.1002/rmb2.12536

Mio Kobayashi, Orie Nakamura, Yoshikazu Kitahara, Naoki Inoue, Yumiko Tsukui, Yuko Hasegawa, Hikaru Hiraishi, Atsushi Yabuki, Ayako Muraoka, Satoko Osuka, Akira Iwase

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Abstract

Purpose: This study aimed to investigate whether serum leucine-rich α2-glycoprotein (LRG) is a useful diagnostic biomarker for endometriosis, including the evaluation of treatment efficacy and exploration of LRG production in endometriotic lesions.

Methods: Forty-three women with endometriomas were compared to 22 women with benign ovarian cysts and 30 women who underwent assisted reproduction as controls. Changes in serum LRG levels were assessed before and after surgery, and during dienogest treatment. LRG expression in endometriotic tissue samples was evaluated using immunoblotting.

Results: Serum LRG levels in the endometrioma group (80.0 ± 36.3 μg/mL) were significantly higher than those in the benign ovarian cyst (65.1 ± 27.0 μg/mL, p = 0.0265) and control (57.8 ± 22.3 μg/mL, p = 0.0028) groups. Serum LRG levels after endometrioma surgery were significantly lower than preoperative levels (p = 0.0484). Serum LRG levels consistently decreased during dienogest treatment. LRG expression levels were significantly higher in endometriotic tissues than in the normal endometrium.

Conclusion: Serum LRG, possibly derived from local and systemic origins, could be used as a potential biomarker for the diagnosis and treatment of endometriosis.

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血清富亮氨酸 α2-糖蛋白可能是子宫内膜异位症炎症状态的标记物。

目的：本研究旨在探讨血清富亮氨酸α2-糖蛋白（LRG）是否是诊断子宫内膜异位症的有效生物标志物，包括评估治疗效果和探讨子宫内膜异位症病灶中 LRG 的产生：方法：将 43 名患有子宫内膜异位症的妇女与 22 名患有良性卵巢囊肿的妇女和 30 名接受辅助生殖的妇女作为对照。评估了手术前后和地诺孕酮治疗期间血清 LRG 水平的变化。使用免疫印迹法评估了子宫内膜异位组织样本中 LRG 的表达情况：结果：子宫内膜异位症组的血清LRG水平（80.0 ± 36.3 μg/mL）明显高于良性卵巢囊肿组（65.1 ± 27.0 μg/mL，p = 0.0265）和对照组（57.8 ± 22.3 μg/mL，p = 0.0028）。子宫内膜瘤手术后的血清LRG水平明显低于术前水平（p = 0.0484）。在地诺孕酮治疗期间，血清 LRG 水平持续下降。子宫内膜异位组织中的LRG表达水平明显高于正常子宫内膜：结论：血清LRG可能来自局部和全身，可作为诊断和治疗子宫内膜异位症的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.