Mefloquine-Induced Inner Ear Damage and Preventive Effects of Electrical Stimulation: An Electrophysiological Study.

IF 1.6 4区医学 Q2 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Audiology and Neuro-Otology Pub Date : 2024-01-01 Epub Date: 2023-08-22 DOI:10.1159/000531788

Mohammad Mahdi Ali-Nazari, Nariman Rahbar, Hassan Haddadzade Niri, Behnoosh Vasaghi-Gharamaleki

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引用次数: 0

Abstract

Introduction: Mefloquine is an antimalarial medicine used to prevent and treat malaria. This medicine has some side effects, including ototoxicity. This study, which was designed in two phases, aimed to investigate the side effects of mefloquine and evaluate the preventive effects of electrical stimulation on these side effects.

Methods: In the first phase, two doses of mefloquine (50 and 200 μM) were injected into male rats, and after 7 days, they were evaluated by an auditory brainstem response (ABR) test. In the second phase, electrical stimulation was applied for 10 days, and then a toxic dose of mefloquine was injected. Similar to the first phase of the study, the animals were evaluated by an ABR test after 7 days.

Results: In the first phase, the results showed that a high dose of mefloquine increased the ABR threshold and wave I latency; however, these changes were not observed in the second phase.

Conclusion: Application of electrical stimulation could prevent the ototoxic effects of mefloquine. According to the findings of the present study, electrical stimulation can be used as a preconditioner to prevent the ototoxic effects of mefloquine.

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甲氟喹诱发的内耳损伤和电刺激的预防作用：电生理学研究

简介甲氟喹是一种抗疟疾药物，用于预防和治疗疟疾。这种药物有一些副作用，包括耳毒性。本研究分两个阶段进行，旨在调查甲氟喹的副作用，并评估电刺激对这些副作用的预防效果：第一阶段，给雄性大鼠注射两种剂量的甲氟喹（50 和 200 μM），7 天后进行听性脑干反应（ABR）测试。在第二阶段，对大鼠进行为期 10 天的电刺激，然后注射毒性剂量的甲氟喹。与第一阶段研究类似，7 天后对动物进行 ABR 测试评估：结果：在第一阶段，结果显示高剂量甲氟喹增加了 ABR 阈值和 I 波潜伏期；但在第二阶段没有观察到这些变化：结论：应用电刺激可预防甲氟喹的耳毒性效应。根据本研究的结果，电刺激可作为预防甲氟喹耳毒性作用的前提条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Audiology and Neuro-Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： ''Audiology and Neurotology'' provides a forum for the publication of the most-advanced and rigorous scientific research related to the basic science and clinical aspects of the auditory and vestibular system and diseases of the ear. This journal seeks submission of cutting edge research opening up new and innovative fields of study that may improve our understanding and treatment of patients with disorders of the auditory and vestibular systems, their central connections and their perception in the central nervous system. In addition to original papers the journal also offers invited review articles on current topics written by leading experts in the field. The journal is of primary importance for all scientists and practitioners interested in audiology, otology and neurotology, auditory neurosciences and related disciplines.