Impact of the COVID-19 pandemic on Clostridioides difficile infection in a tertiary healthcare institution in Belgium.

IF 1.6 4区 医学 Q2 Medicine
Acta Clinica Belgica Pub Date : 2023-12-01 Epub Date: 2023-08-23 DOI:10.1080/17843286.2023.2250624
Bastien Tossens, Philippe Barthelme, Caroline Briquet, Leila Belkhir, Eléonore Ngyuvula, Kate Soumillion, Alexia Verroken, Hector Rodriguez-Villalobos, Michel Delmée, Ahalieyah Anantharajah
{"title":"Impact of the COVID-19 pandemic on <i>Clostridioides difficile</i> infection in a tertiary healthcare institution in Belgium.","authors":"Bastien Tossens,&nbsp;Philippe Barthelme,&nbsp;Caroline Briquet,&nbsp;Leila Belkhir,&nbsp;Eléonore Ngyuvula,&nbsp;Kate Soumillion,&nbsp;Alexia Verroken,&nbsp;Hector Rodriguez-Villalobos,&nbsp;Michel Delmée,&nbsp;Ahalieyah Anantharajah","doi":"10.1080/17843286.2023.2250624","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Clostridioides difficile infection (CDI) causes the greatest number of healthcare-associated infectious diarrhoea. CDIs are transmitted by direct and indirect patient-to-patient contact and risk increases with the use of antibiotics. Since early 2020, the COVID-19 pandemic has affected healthcare systems in many ways including substantial changes in hygiene behaviour. The aim of this study was to assess whether CDI incidence differed during the COVID-19 pandemic compared to a year before.</p><p><strong>Methods: </strong>All tests for suspected CDI cases were recorded for a hospital in Brussels, Belgium. The percentage of CDI-positive results and incidences (total and healthcare-associated (HA)-CDI)) for years 2019, 2020, 2021, and 2022 were calculated. Antibiotic consumption was analysed for years 2019 and 2020.</p><p><strong>Results: </strong>Since the COVID-19 pandemic struck, a significant reduction of up to 39% was observed in the number of <i>Clostridioides difficile</i> stool tests in our hospital. A significant decrease in the percentage of positive tests and a 50% decrease in the incidence of CDI (total and HA-CDI) was found for 2020 compared with 2019 and confirmed for years 2021 and 2022. The decrease in CDI incidence was mostly marked in haematology, nephrology, and gastroenterology units. No significant change in the use of antibiotics was found.</p><p><strong>Conclusion: </strong>The global decrease in CDI incidence observed in our hospital was not associated with a change in the use of antibiotics. The control measures implemented to prevent COVID-19 transmission may explain a reduction in CDI incidence. An underdiagnosis of CDI cannot be excluded.</p>","PeriodicalId":7086,"journal":{"name":"Acta Clinica Belgica","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Clinica Belgica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17843286.2023.2250624","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/23 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

Objectives: Clostridioides difficile infection (CDI) causes the greatest number of healthcare-associated infectious diarrhoea. CDIs are transmitted by direct and indirect patient-to-patient contact and risk increases with the use of antibiotics. Since early 2020, the COVID-19 pandemic has affected healthcare systems in many ways including substantial changes in hygiene behaviour. The aim of this study was to assess whether CDI incidence differed during the COVID-19 pandemic compared to a year before.

Methods: All tests for suspected CDI cases were recorded for a hospital in Brussels, Belgium. The percentage of CDI-positive results and incidences (total and healthcare-associated (HA)-CDI)) for years 2019, 2020, 2021, and 2022 were calculated. Antibiotic consumption was analysed for years 2019 and 2020.

Results: Since the COVID-19 pandemic struck, a significant reduction of up to 39% was observed in the number of Clostridioides difficile stool tests in our hospital. A significant decrease in the percentage of positive tests and a 50% decrease in the incidence of CDI (total and HA-CDI) was found for 2020 compared with 2019 and confirmed for years 2021 and 2022. The decrease in CDI incidence was mostly marked in haematology, nephrology, and gastroenterology units. No significant change in the use of antibiotics was found.

Conclusion: The global decrease in CDI incidence observed in our hospital was not associated with a change in the use of antibiotics. The control measures implemented to prevent COVID-19 transmission may explain a reduction in CDI incidence. An underdiagnosis of CDI cannot be excluded.

新冠肺炎大流行对比利时一家三级医疗机构艰难梭菌感染的影响。
目的:艰难梭菌感染(CDI)引起的医疗保健相关感染性腹泻数量最多。CDIs通过直接和间接的患者间接触传播,使用抗生素的风险会增加。自2020年初以来,新冠肺炎大流行在许多方面影响了医疗系统,包括卫生行为的重大变化。本研究的目的是评估新冠肺炎大流行期间CDI发病率是否与前一年有所不同。方法:在比利时布鲁塞尔的一家医院记录所有疑似CDI病例的检测结果。计算了2019年、2020年、2021年和2022年CDI阳性结果和发病率(总发病率和医疗保健相关(HA)-CDI)的百分比。分析了2019年和2020年的抗生素消费情况。结果:自新冠肺炎大流行以来,我们医院的艰难梭菌粪便检测数量显著减少了39%。与2019年相比,2020年的阳性检测百分比显著下降,CDI(总CDI和HA-CDI)发病率下降50%,并在2021年和2022年得到证实。CDI发病率的下降主要表现在血液学、肾脏学和胃肠科。抗生素的使用没有发现显著变化。结论:在我们医院观察到的CDI发病率的全球下降与抗生素使用的变化无关。为预防新冠肺炎传播而实施的控制措施可以解释CDI发病率下降的原因。不能排除CDI的诊断不足。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Acta Clinica Belgica
Acta Clinica Belgica 医学-医学:内科
CiteScore
2.90
自引率
0.00%
发文量
44
审稿时长
6-12 weeks
期刊介绍: Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine primarily publishes papers on clinical medicine, clinical chemistry, pathology and molecular biology, provided they describe results which contribute to our understanding of clinical problems or describe new methods applicable to clinical investigation. Readership includes physicians, pathologists, pharmacists and physicians working in non-academic and academic hospitals, practicing internal medicine and its subspecialties.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信