Unfolded Protein Response Signaling in Hepatic Stem Cell Activation in Liver Fibrosis.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Zohreh Salimi, Mehdi Rostami, Yaser Eshaghi Milasi, Alireza Mafi, Ramin Raoufinia, Amirhossein Kiani, Fariba Sakhaei, Behrooz Ghezelbash, Alexandra E Butler, Maryam Mohammad-Sadeghipour, Amirhossein Sahebkar
{"title":"Unfolded Protein Response Signaling in Hepatic Stem Cell Activation in Liver Fibrosis.","authors":"Zohreh Salimi, Mehdi Rostami, Yaser Eshaghi Milasi, Alireza Mafi, Ramin Raoufinia, Amirhossein Kiani, Fariba Sakhaei, Behrooz Ghezelbash, Alexandra E Butler, Maryam Mohammad-Sadeghipour, Amirhossein Sahebkar","doi":"10.2174/1389203724666230822085951","DOIUrl":null,"url":null,"abstract":"<p><p>Frequent exposure to various external and internal adverse forces (stresses) disrupts cell protein homeostasis through endoplasmic reticulum (ER) capacity saturation. This process leads to the unfolded protein response (UPR), which aims to re-establish/maintain optimal cellular equilibrium. This complex mechanism is involved in the pathogenesis of various disorders, such as metabolic syndrome, fibrotic diseases, neurodegeneration, and cancer, by altering cellular metabolic changes integral to activating the hepatic stellate cells (HSCs). The development of hepatic fibrosis is one of the consequences of UPR activation. Therefore, novel therapies that target the UPR pathway effectively and specifically are being studied. This article covers the involvement of the UPR signaling pathway in cellular damage in liver fibrosis. Investigating the pathogenic pathways related to the ER/UPR stress axis that contribute to liver fibrosis can help to guide future drug therapy approaches.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.2174/1389203724666230822085951","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Frequent exposure to various external and internal adverse forces (stresses) disrupts cell protein homeostasis through endoplasmic reticulum (ER) capacity saturation. This process leads to the unfolded protein response (UPR), which aims to re-establish/maintain optimal cellular equilibrium. This complex mechanism is involved in the pathogenesis of various disorders, such as metabolic syndrome, fibrotic diseases, neurodegeneration, and cancer, by altering cellular metabolic changes integral to activating the hepatic stellate cells (HSCs). The development of hepatic fibrosis is one of the consequences of UPR activation. Therefore, novel therapies that target the UPR pathway effectively and specifically are being studied. This article covers the involvement of the UPR signaling pathway in cellular damage in liver fibrosis. Investigating the pathogenic pathways related to the ER/UPR stress axis that contribute to liver fibrosis can help to guide future drug therapy approaches.

肝纤维化中肝脏干细胞活化过程中的折叠蛋白反应信号传导
频繁暴露于各种外部和内部不利力量(压力)之下,会导致内质网(ER)容量饱和,从而破坏细胞蛋白质的平衡。这一过程导致了旨在重建/维持最佳细胞平衡的未折叠蛋白反应(UPR)。这种复杂的机制通过改变激活肝星状细胞(HSCs)不可或缺的细胞代谢变化,参与了代谢综合征、纤维化疾病、神经变性和癌症等各种疾病的发病机制。肝纤维化的发展是 UPR 激活的后果之一。因此,针对 UPR 通路进行有效和特异性治疗的新型疗法正在研究之中。本文介绍了 UPR 信号通路参与肝纤维化中细胞损伤的情况。研究与导致肝纤维化的ER/UPR应激轴相关的致病途径有助于指导未来的药物治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信