Evaluation of standard versus prolonged magnesium infusion rates in hospitalized patients: a retrospective cohort study.

IF 1.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Magnesium research Pub Date : 2023-03-01 DOI:10.1684/mrh.2023.0512

Halah Yaldo, Renee Paxton, Christopher Giuliano

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引用次数: 0

Abstract

Background: Hypomagnesemia is a common electrolyte abnormality in hospitalized patients. Prolonging the infusion rate of magnesium has been hypothesized to increase retention of magnesium, however, there is limited evidence to support prolonging the rate of infusion.

Aim: To compare the absolute change in serum magnesium levels from baseline to levels drawn within 24 hours after the end of infusion between two groups receiving standard or prolonged infusion.

Methods: This was a retrospective, observational cohort study comparing patients receiving magnesium infusion at a standard rate of 0.5 gm/h to those receiving magnesium infusion at a prolonged rate of 0.17 gm/h.

Results: Of a total of 276 patients, 138 were included in each group. No differences existed between the groups for any demographic variables (all p>0.05). The absolute change in serum magnesium level was 0.41 mg/dL versus 0.31 mg/dL in the standard and the prolonged infusion groups, respectively (p = 0.001). The length of stay after the initial magnesium dose was slightly longer with the prolonged infusion compared to the standard infusion, with a median of 2.9 days versus 3.6 days, respectively (p = 0.02). No differences existed between the groups for any secondary or safety outcomes (all p>0.05).

Conclusion: Hospitalized general patients did not benefit from the prolonged infusion of magnesium compared to standard infusion.

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住院患者标准与延长镁输注速率的评价:一项回顾性队列研究

背景:低镁血症是住院患者常见的电解质异常。延长镁的输注速度被认为可以增加镁的潴留，然而，支持延长输注速度的证据有限。目的:比较两组标准输注组和延长输注组血清镁水平从基线到输注结束后24小时内的绝对变化。方法:这是一项回顾性、观察性队列研究，比较了以0.5 gm/h的标准速率接受镁输注的患者和以0.17 gm/h的延长速率接受镁输注的患者。结果:276例患者中，每组138例。组间人口统计学变量均无差异(p>0.05)。血清镁水平的绝对变化为0.41 mg/dL，而标准组和延长输注组分别为0.31 mg/dL (p = 0.001)。与标准输注相比，延长输注镁初始剂量后的停留时间略长，中位数分别为2.9天和3.6天(p = 0.02)。两组间的次要或安全性指标均无差异(均p>0.05)。结论:与标准输注相比，住院普通患者并没有从长时间输注镁中获益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnesium research 医学-内分泌学与代谢

CiteScore

3.50

自引率

9.40%

发文量

审稿时长

>12 weeks

期刊介绍： Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.