Structural basis for respiratory syncytial virus and human metapneumovirus neutralization

IF 5.7 2区 医学 Q1 VIROLOGY
Rose J Miller , Jarrod J Mousa
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引用次数: 0

Abstract

Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) continue to be a global burden to infants, the elderly, and immunocompromised individuals. In the past ten years, there has been substantial progress in the development of new vaccine candidates and therapies against these viruses. These advancements were guided by the structural elucidation of the major surface glycoproteins for these viruses, the fusion (F) protein and attachment (G) protein. The identification of immunodominant epitopes on the RSV F and hMPV F proteins has expanded current knowledge on antibody-mediated immune responses, which has led to new approaches for vaccine and therapeutic development through the stabilization of pre-fusion constructs of the F protein and pre-fusion-specific monoclonal antibodies with high potency and efficacy. In this review, we describe structural characteristics of known antigenic sites on the RSV and hMPV proteins, their influence on the immune response, and current progress in vaccine and therapeutic development.

呼吸道合胞病毒和人偏肺病毒中和的结构基础
呼吸道合胞病毒(RSV)和人类偏肺病毒(hMPV)仍然是婴儿、老年人和免疫功能低下者的全球负担。在过去的十年里,针对这些病毒的新候选疫苗和疗法的开发取得了实质性进展。这些进展是由这些病毒的主要表面糖蛋白,融合(F)蛋白和附着(G)蛋白的结构阐明所指导的。RSV F和hMPV F蛋白上免疫显性表位的鉴定扩展了抗体介导的免疫反应的现有知识,这通过稳定F蛋白的预融合构建体和具有高效力和效力的预融合特异性单克隆抗体,为疫苗和治疗开发开辟了新的途径。在这篇综述中,我们描述了RSV和hMPV蛋白上已知抗原位点的结构特征,它们对免疫反应的影响,以及疫苗和治疗开发的最新进展。
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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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