NK cell-based tumor immunotherapy

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2023-08-09 DOI:10.1016/j.bioactmat.2023.08.001

Hao Zhang, Li Yang, Tingting Wang, Zhen Li

引用次数: 2

Abstract

Natural killer (NK) cells display a unique inherent ability to identify and eliminate virus-infected cells and tumor cells. They are particularly powerful for elimination of hematological cancers, and have attracted considerable interests for therapy of solid tumors. However, the treatment of solid tumors with NK cells are less effective, which can be attributed to the very complicated immunosuppressive microenvironment that may lead to the inactivation, insufficient expansion, short life, and the poor tumor infiltration of NK cells. Fortunately, the development of advanced nanotechnology has provided potential solutions to these issues, and could improve the immunotherapy efficacy of NK cells. In this review, we summarize the activation and inhibition mechanisms of NK cells in solid tumors, and the recent advances in NK cell-based tumor immunotherapy boosted by diverse nanomaterials. We also propose the challenges and opportunities for the clinical application of NK cell-based tumor immunotherapy.

Abstract Image

查看原文本刊更多论文

基于NK细胞的肿瘤免疫治疗

自然杀伤细胞（NK）显示出识别和消除病毒感染的细胞和肿瘤细胞的独特固有能力。它们在消除血液系统癌症方面特别强大，并在实体瘤治疗方面引起了相当大的兴趣。然而，NK细胞治疗实体瘤的效果较差，这可归因于非常复杂的免疫抑制微环境，可能导致NK细胞失活、扩增不足、寿命短和肿瘤浸润不良。幸运的是，先进纳米技术的发展为这些问题提供了潜在的解决方案，并可能提高NK细胞的免疫治疗效果。在这篇综述中，我们总结了NK细胞在实体瘤中的激活和抑制机制，以及各种纳米材料促进的基于NK细胞的肿瘤免疫治疗的最新进展。我们还提出了基于NK细胞的肿瘤免疫疗法临床应用的挑战和机遇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.