Investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancer.

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2023-08-17 eCollection Date: 2023-01-01 DOI:10.1002/rmb2.12534

Hiroki Takeuchi, Tadashi Maezawa, Katsuyuki Hagiwara, Yuki Horage, Tetsuro Hanada, Huang Haipeng, Mito Sakamoto, Mikiko Nishioka, Erina Takayama, Kento Terada, Eiji Kondo, Yasushi Takai, Nao Suzuki, Tomoaki Ikeda

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引用次数: 0

Abstract

Purpose: To examine the optimal timing of second ovarian stimulation using the dual stimulation method for good ovarian responders with cancer undergoing oocyte retrieval for fertility preservation.

Methods: A retrospective analysis was conducted using data from 69 patients with cancer who underwent oocyte retrieval for fertility preservation at four Japanese institutions during 2010-2021. Twenty-two patients underwent two oocyte retrievals for fertility preservation. We studied the relationship between the initial number of oocytes retrieved via dual stimulation and risk of ovarian enlargement as well as the appropriate waiting interval between the end of the first ovarian stimulation and beginning of the second ovarian stimulation.

Results: The risk of ovarian enlargement was high when the initial number of oocytes retrieved via dual stimulation was ≥5. An 8-day waiting interval may be more effective for performing a second ovarian stimulation oocyte retrieval in these cases, although the difference was not significant.

Conclusions: This study provides one policy for effectively managing ovarian enlargement and timing of second ovarian stimulation during oocyte retrieval via the dual stimulation method for patients with cancer undergoing fertility preservation. If more facilities implement this procedure, more oocytes may be obtained in a short period for fertility preservation purposes.

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研究一种通过双重刺激为癌症患者提取卵母细胞的有效方法。

目的：研究对卵巢反应良好的癌症患者进行卵母细胞提取以保留生育能力时，使用双重刺激法进行第二次卵巢刺激的最佳时机：方法：利用 2010-2021 年间在日本四家医疗机构接受卵母细胞提取术以保留生育能力的 69 名癌症患者的数据进行回顾性分析。其中，22 名患者接受了两次卵母细胞取回手术以保留生育能力。我们研究了通过双重刺激获取的初始卵母细胞数量与卵巢增大风险之间的关系，以及第一次卵巢刺激结束与第二次卵巢刺激开始之间的适当等待间隔：结果：当通过双重刺激获取的初始卵母细胞数≥5个时，卵巢增大的风险很高。在这些情况下，间隔 8 天进行第二次促排卵取卵可能更有效，但差异并不显著：本研究为接受生育力保存的癌症患者在通过双刺激法取卵期间有效管理卵巢增大和第二次卵巢刺激的时机提供了一项政策。如果有更多的医疗机构采用这种方法，就能在短时间内获得更多的卵母细胞用于生育力保存。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.